Inhibitory Activities of Pancreatic Lipase and Phosphodiesterase from Korean Medicinal Plant Extracts

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 中国科学院东亚植物多样性与生物地理学重点实验室

	Inhibitory Activities of Pancreatic Lipase and Phosphodiesterase from Korean Medicinal Plant Extracts
	Lee, Yun Mi 1; Kim, Young Sook 1; Lee, Youngseop 1; Kim, Junghyun 1; Sun, Hang2 ; Kim, Joo Hwan 3; Kim, Jin Sook 1
刊名	PHYTOTHERAPY RESEARCH
	2012-05-01
卷号	26 期号:5 页码:778-782
关键词	pancreatic lipase phosphodiesterase Korean medicinal plants Sorbus commixta Viscum album
ISSN号	0951-418X
通讯作者	Kim, JS (reprint author), KIOM, Diabet Complicat Res Ctr, Div Tradit Korean Med TKM Integrated Res, 483 Exporo, Taejon 305811, South Korea, jskim@kiom.re.kr
英文摘要	To find new pancreatic lipase (triacylgycerol acylhydrolase, EC 3.1.1.3) inhibitors from natural products, 61 medicinal plants from Korea were screened for their antilipase activity for prevention of obesity. Dried and powdered plants were extracted three times with EtOH and extracts were obtained by removal of the solvent in vacuo. Lipase activity was determined by measuring the hydrolysis of p-nitrophenyl butyrate to p-nitrophenol. Also, the inhibitory effect was measured on phosphodiesterase (PDE), another therapeutic target for obesity. Of the extracts tested, Sorbus commixta (stem, leaf) and Viscum album (whole plant) exhibited antilipase activity (with IC50 values of 29.6?mu g/mL and 33.3?mu g/mL, respectively) and only anti-PDE activity (IC50 values of 20.08?mu g/mL and 35.15?mu g/mL, respectively). Copyright (c) 2011 John Wiley & Sons, Ltd.
学科主题	Chemistry, Medicinal; Pharmacology & Pharmacy
类目[WOS]	Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]	Pharmacology & Pharmacy
关键词[WOS]	SORBUS-COMMIXTA ; OBESITY
收录类别	SCI
资助信息	Korea Research Council of Fundamental Science and Technology (KRCF)[G10100]; Korea Institute of Oriental Medicine (KIOM)[K10040]
语种	英语
WOS记录号	WOS:000302936700023
公开日期	2012-06-07
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/10475]
专题	昆明植物研究所_中国科学院东亚植物多样性与生物地理学重点实验室
作者单位	1.KIOM, Diabet Complicat Res Ctr, Div Tradit Korean Med TKM Integrated Res, Taejon 305811, South Korea 2.Chinese Acad Sci, Lab Biodivers & Biogeog, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China 3.Kyungwon Univ, Dept Life Sci, Songnam 461701, Kyonggi Do, South Korea
推荐引用方式 GB/T 7714	Lee, Yun Mi,Kim, Young Sook,Lee, Youngseop,et al. Inhibitory Activities of Pancreatic Lipase and Phosphodiesterase from Korean Medicinal Plant Extracts[J]. PHYTOTHERAPY RESEARCH,2012,26(5):778-782.
APA	Lee, Yun Mi.,Kim, Young Sook.,Lee, Youngseop.,Kim, Junghyun.,Sun, Hang.,...&Kim, Jin Sook.(2012).Inhibitory Activities of Pancreatic Lipase and Phosphodiesterase from Korean Medicinal Plant Extracts.PHYTOTHERAPY RESEARCH,26(5),778-782.
MLA	Lee, Yun Mi,et al."Inhibitory Activities of Pancreatic Lipase and Phosphodiesterase from Korean Medicinal Plant Extracts".PHYTOTHERAPY RESEARCH 26.5(2012):778-782.