DNA damage of germ cell of rat induced by nitrotoluene chemicals

	DNA damage of germ cell of rat induced by nitrotoluene chemicals
	Zhen Lin
	2005
关键词	Cell culture DNA Electrophoresis Nitrogen compounds Toluene Toxicity
英文摘要	2,4-dinitrotoluene (2,4-DNT), 2,6-dinitrotoluene (2,6-DNT) and 4-nitrotoluene (4-NT) are typical pollutants in the Songhua River of Northeast China. Sertoli/germ cell cocultures and single cell gel electrophoresis (SCGE) are applied to investigate whether they have genotoxicity on DNA damage of germ cell of Kunming male rat. The results showed that all three nitrotoluene compounds tested could induce DNA single-strand breaks of the germ cell. A significant relationship is found between logarithm dose and the degree of DNA damage, which implies that 2,4-DNT, 2,6-DNT and 4-NT have genotoxicity and can induce the germ cell DNA strand to break in vitro. © 2005 Science Press. All rights reserved.
出处	Journal of Environmental Sciences
卷	17 期:1 页:84-90
收录类别	EI
语种	英语
内容类型	EI期刊论文
源URL	[http://ir.igsnrr.ac.cn/handle/311030/24438]
专题	地理科学与资源研究所_历年回溯文献
推荐引用方式 GB/T 7714	Zhen Lin. DNA damage of germ cell of rat induced by nitrotoluene chemicals. 2005.