Preparation of photo-cross-linked pH-responsive polypeptide nanogels as potential carriers for controlled drug delivery

	Preparation of photo-cross-linked pH-responsive polypeptide nanogels as potential carriers for controlled drug delivery
	Ding JX ; Zhuang XL ; Xiao CS ; Cheng YL ; Zhao L ; He CL ; Tang ZH ; Chen XS
刊名	journal of materials chemistry
	2011
卷号	21 期号:30 页码:11383-11391
关键词	ABC TRIBLOCK COPOLYMERS BLOCK-COPOLYMERS MICELLES RELEASE POLYMERIZATION NANOPARTICLES HYDROGELS POLYMERS ACID)
ISSN号	0959-9428
通讯作者	chen xs
中文摘要	diblock and triblock copolymers, including poly(ethylene glycol monomethyl ether)-b-poly(l-glutamic acid-co-gamma-cinnamyl-l-glutamate) (mpeg-b-p(lga/clg)) and poly(l-glutamic acid-co-gamma-cinnamyl-l-glutamate)-b-poly(ethylene glycol)-b-poly(l-glutamic acid-co-gamma-cinnamyl-l-glutamate) (p(lga/clg)-b-peg-b-p(lga/clg)), were synthesized by ring-opening polymerization (rop) of gamma-benzyl-l-glutamate-n-carboxyanhydride (blg-nca) monomer with peg-based macroinitiator, deprotection of the benzyl groups and subsequent chemical modification with cinnamyl alcohol. the structures of copolymers were confirmed by (1)h nmr and gpc analyses. pyrene-probe-based fluorescence technique revealed that these diblock and triblock copolymers could self-assemble into micelles in aqueous solution at ph 7.4 spontaneously, with peg shells and p(lga/clg) cores. under uv-irradiation at lambda = 254 nm, the p(lga/clg) blocks in the cores of the micelles were cross-linked through the photodimerization of the cinnamyloxy groups, yielding nanogels. the nanogels were characterized by (1)h nmr, ft-ir, sem, afm and dls. the nanogels were ph-responsive and their properties could be tuned by varying the compositions of block copolymers. in vitro mtt assay demonstrated that the nanogels were biocompatible to hela cells, rendering their potential for drug delivery applications. rifampin as a model drug was loaded into the nanogels. the in vitro rifampin release behaviors of nanogels could be affected by both the compositions of block copolymers and solution ph. these properties indicated that the ph-responsive nanogels fabricated by photo-cross-linking polypeptide micelles can be used as drug carriers for intelligent drug delivery.
收录类别	SCI收录期刊论文
语种	英语
WOS记录号	WOS:000292974400050
公开日期	2012-06-11
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/44967]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Ding JX,Zhuang XL,Xiao CS,et al. Preparation of photo-cross-linked pH-responsive polypeptide nanogels as potential carriers for controlled drug delivery[J]. journal of materials chemistry,2011,21(30):11383-11391.
APA	Ding JX.,Zhuang XL.,Xiao CS.,Cheng YL.,Zhao L.,...&Chen XS.(2011).Preparation of photo-cross-linked pH-responsive polypeptide nanogels as potential carriers for controlled drug delivery.journal of materials chemistry,21(30),11383-11391.
MLA	Ding JX,et al."Preparation of photo-cross-linked pH-responsive polypeptide nanogels as potential carriers for controlled drug delivery".journal of materials chemistry 21.30(2011):11383-11391.