Synthesis of temperature and pH-responsive crosslinked micelles from polypeptide-based graft copolymer

	Synthesis of temperature and pH-responsive crosslinked micelles from polypeptide-based graft copolymer
	Zhao CW ; He P ; Xiao CS ; Gao XY ; Zhuang XL ; Chen XS
刊名	journal of colloid and interface science
	2011
卷号	359 期号:2 页码:436-442
关键词	POLY N-ISOPROPYLACRYLAMIDE SCHIZOPHRENIC DIBLOCK COPOLYMER HYDROPHILIC BLOCK-COPOLYMERS AQUEOUS-SOLUTION PROPERTIES ABC TRIBLOCK COPOLYMERS DRUG-DELIVERY BIOMEDICAL APPLICATIONS MICELLIZATION WATER CORE
ISSN号	0021-9797
通讯作者	zhuang xl
中文摘要	a polypeptide-based double hydrophilic graft copolymer was synthesized by the sequential grafting of poly(n-isopropylacrylamide) (pnipam) and 2-hydroxyethyl methacrylate (hema) onto poly(l-glutamic acid) (pga) backbone. the copolymers were sensitive to both temperature and ph. the phase transition and aggregation behaviors of the graft copolymers in aqueous solutions were investigated by the turbidity measurements and dynamic laser scattering (dls). the light transmittance decrease of the copolymers at temperature above lower critical solution temperature (lcst) was remarkably weakened at ph around 6.5 due to the coil to alpha helix change of pga chain induced by ph. the copolymers can self-assembly into micelles with pnipam cores in the aqueous solution at ph 8.0 and 60 degrees c. subsequently, polymerization of hema led to the facile preparation of crosslinked micelles, which were observed directly by transmission electron microscopy (tem). the temperature controlled shrinkage behaviors of crosslinked micelles highly depended on the ph values of the solution. the crosslinked micelles aggregated at ph 5.0 due to the increased hydrophobic interactions among them induced by the protonation of pga component. these crosslinked micelles have promising applications as intelligent drug delivery vehicles. (c) 2011 elsevier inc. all rights reserved.
收录类别	SCI收录期刊论文
语种	英语
WOS记录号	WOS:000290973800014
公开日期	2012-06-08
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/44472]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Zhao CW,He P,Xiao CS,et al. Synthesis of temperature and pH-responsive crosslinked micelles from polypeptide-based graft copolymer[J]. journal of colloid and interface science,2011,359(2):436-442.
APA	Zhao CW,He P,Xiao CS,Gao XY,Zhuang XL,&Chen XS.(2011).Synthesis of temperature and pH-responsive crosslinked micelles from polypeptide-based graft copolymer.journal of colloid and interface science,359(2),436-442.
MLA	Zhao CW,et al."Synthesis of temperature and pH-responsive crosslinked micelles from polypeptide-based graft copolymer".journal of colloid and interface science 359.2(2011):436-442.