Metabolomic profiles delineate potential roles for gadolinium chloride in the proliferation or inhibition of Hela cells

	Metabolomic profiles delineate potential roles for gadolinium chloride in the proliferation or inhibition of Hela cells
	Long XH ; Yang PY ; Liu Q ; Yao J ; Wang Y ; He GH ; Hong GY ; Ni JZ
刊名	biometals
	2011
卷号	24 期号:4 页码:663-667
关键词	SYSTEMS BIOLOGY CANCER-CELLS CALCIUM ANTIOXIDANTS METABONOMICS ACTIVATION PATHWAYS AGENTS ENTRY
ISSN号	0966-0844
通讯作者	long xh
中文摘要	lanthanides (lns) compounds have been reported to possess contrary effects on cell activity, i.e., promoting cell cycle progression and cell growth by lower concentration treatment, but suppressing cell proliferation and inducing cell apoptosis at higher dosing. however, the cellular processes during the intervention and the possible underlying mechanisms are still not well clarified. using a combination of high-throughput liquid chromatography (lc) with mass spectrometry (ms), we have investigated the metabolomic profiles of hela cells following gadolinium chloride (gdcl(3)) treatment in time- and concentration- dependent manners. a total of 48 metabolites released by hela cells are identified to be differentially expressed (p < 0.05) in different states. metabolic pathways analyses reveal that the differential metabolites are mainly characterized by increased lipid and amino acid metabolisms and by decreased lipid, amino acid, and carbohydrate metabolisms for cells treated with gdcl(3) at lower and higher concentrations, respectively. notably, in the higher level gdcl(3) case, the down-expressions of metabolites are predominantly in the glycolytic and the redox pathways. the above results, obtained by using a metabolomic strategy for the first time, disclose that different cell signaling pathways are activated by gdcl(3) treatment with different concentrations, leading to inhibitory or promotional effect on hela cells.
收录类别	SCI收录期刊论文
语种	英语
WOS记录号	WOS:000292041400007
公开日期	2012-06-08
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/44447]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Long XH,Yang PY,Liu Q,et al. Metabolomic profiles delineate potential roles for gadolinium chloride in the proliferation or inhibition of Hela cells[J]. biometals,2011,24(4):663-667.
APA	Long XH.,Yang PY.,Liu Q.,Yao J.,Wang Y.,...&Ni JZ.(2011).Metabolomic profiles delineate potential roles for gadolinium chloride in the proliferation or inhibition of Hela cells.biometals,24(4),663-667.
MLA	Long XH,et al."Metabolomic profiles delineate potential roles for gadolinium chloride in the proliferation or inhibition of Hela cells".biometals 24.4(2011):663-667.