Layer-by-layer assembly of poly(L-glutamic acid)/chitosan microcapsules for high loading and sustained release of 5-fluorouracil

	Layer-by-layer assembly of poly(L-glutamic acid)/chitosan microcapsules for high loading and sustained release of 5-fluorouracil
	Yan SF ; Zhu J ; Wang ZC ; Yin JB ; Zheng YZ ; Chen XS
刊名	european journal of pharmaceutics and biopharmaceutics
	2011
卷号	78 期号:3 页码:336-345
关键词	POLYELECTROLYTE MULTILAYER CAPSULES DRUG-DELIVERY SYSTEMS IN-VITRO SPONTANEOUS DEPOSITION ACID) MICROSPHERES CHITOSAN NANOPARTICLES MACROMOLECULES ENCAPSULATION PERMEABILITY
ISSN号	0935-1221
通讯作者	yin jb
中文摘要	hollow polyelectrolyte microcapsules based on poly(l-glutamic acid) (plga) and chitosan (cs) with opposite charges were fabricated by layer-by-layer (lbl) assembly technique using melamine formaldehyde (mf) microparticles as sacrificial templates. the lbl assembly of polyelectrolytes and the resultant plga/cs microcapsules were characterized. a hydrophilic anticancer drug, 5-fluorouracil (5-fu), was chosen to investigate the loading and release properties of the microcapsules. the plga/cs microcapsules show high loading capacity of 5-fu under conditions of high drug concentration and salt adding. the high loading can be ascribed to spontaneous deposition of 5-fu induced by hydrogen bonding between 5-fu and plga/cs microcapsules. the plga/cs microcapsules show sustained release behavior. the release rate of 5-fu drastically slows down after loading in plga/cs microcapsules. the 5-fu release from plga/cs microcapsules can be best described using ritger-peppas or baker-londale models, indicating the diffusion mechanism of 5-fu release from the plga/cs microcapsules. in vitro cytotoxicity evaluation by the mtt assay shows good cell viability over the entire concentration range of plga/cs microcapsules. therefore, the novel plga/cs microcapsules are expected to find application in drug delivery systems because of the properties of biodegradability, high loading, sustained release and cell compatibility. (c) 2010 elsevier b.v. all rights reserved.
收录类别	SCI收录期刊论文
语种	英语
WOS记录号	WOS:000294105600005
公开日期	2012-06-08
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/44425]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Yan SF,Zhu J,Wang ZC,et al. Layer-by-layer assembly of poly(L-glutamic acid)/chitosan microcapsules for high loading and sustained release of 5-fluorouracil[J]. european journal of pharmaceutics and biopharmaceutics,2011,78(3):336-345.
APA	Yan SF,Zhu J,Wang ZC,Yin JB,Zheng YZ,&Chen XS.(2011).Layer-by-layer assembly of poly(L-glutamic acid)/chitosan microcapsules for high loading and sustained release of 5-fluorouracil.european journal of pharmaceutics and biopharmaceutics,78(3),336-345.
MLA	Yan SF,et al."Layer-by-layer assembly of poly(L-glutamic acid)/chitosan microcapsules for high loading and sustained release of 5-fluorouracil".european journal of pharmaceutics and biopharmaceutics 78.3(2011):336-345.