Beta structure motifs of islet amyloid polypeptides identified through surface-mediated assemblies

	Beta structure motifs of islet amyloid polypeptides identified through surface-mediated assemblies
	Mao XB ; Wang CX ; Wu XK ; Ma XJ ; Liu L ; Zhang L ; Niu L ; Guo YY ; Li DH ; Yang YL ; Wang C
刊名	proceedings of the national academy of sciences of the united states of america
	2011
卷号	108 期号:49 页码:19605-19610
关键词	HUMAN AMYLIN GLOBULAR-PROTEINS DIABETES-MELLITUS RAT AMYLIN FIBRILS IAPP PEPTIDE LANGERHANS SEQUENCE SEGMENT
ISSN号	0027-8424
通讯作者	yang yl
中文摘要	we report here the identification of the key sites for the beta structure motifs of the islet amyloid polypeptide (iapp) analogs by using scanning tunneling microscopy (stm). duplex folding structures in human iapp(8-37) (hiapp(8-37)) assembly were observed featuring a hairpin structure. the multiplicity in riapp assembly structures indicates the polydispersity of the rat iapp(8-37) (riapp(8-37)) beta-like motifs. the bimodal length distribution of beta structure motifs for riapp(8-37) r18h indicates the multiple beta segments linked by turns. the iapp(8-37) analogs share common structure motifs of iapp(8-17) and iapp(26-37) with the most probable key sites at positions around ser(19)/ser(20) and gly(24). these observations reveal the similar amyloid formation tendency in the c and n terminus segments because of the sequence similarity, while the differences in specific amino acids at each key site manifest the effect of sequence variations. the results could be beneficial for studying structural polymorphism of amyloidal peptides with multiple beta structure motifs.
收录类别	SCI收录期刊论文
语种	英语
WOS记录号	WOS:000297683800040
公开日期	2012-06-07
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/44180]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Mao XB,Wang CX,Wu XK,et al. Beta structure motifs of islet amyloid polypeptides identified through surface-mediated assemblies[J]. proceedings of the national academy of sciences of the united states of america,2011,108(49):19605-19610.
APA	Mao XB.,Wang CX.,Wu XK.,Ma XJ.,Liu L.,...&Wang C.(2011).Beta structure motifs of islet amyloid polypeptides identified through surface-mediated assemblies.proceedings of the national academy of sciences of the united states of america,108(49),19605-19610.
MLA	Mao XB,et al."Beta structure motifs of islet amyloid polypeptides identified through surface-mediated assemblies".proceedings of the national academy of sciences of the united states of america 108.49(2011):19605-19610.