Phase Behavior of Poly(sulfobetaine methacrylate)-Grafted Silica Nanoparticles and Their Stability in Protein Solutions

	Phase Behavior of Poly(sulfobetaine methacrylate)-Grafted Silica Nanoparticles and Their Stability in Protein Solutions
	Dong ZX ; Mao J ; Yang MQ ; Wang DP ; Bo SQ ; Ji XL
刊名	langmuir
	2011
卷号	27 期号:24 页码:15282-15291
关键词	TRANSFER RADICAL POLYMERIZATION SULFOBETAINE POLYMERS ZWITTERIONIC POLYMERS ADSORPTION SURFACE THICKNESS BRUSHES COPOLYMERS RESISTANCE NETWORKS
ISSN号	0743-7463
通讯作者	ji xl
中文摘要	biocompatible and zwitterionic poly(sulfobetaine methacrylate) (psbma) was grafted onto the surface of initiator-modified silica nanopartides via surface-initiated atom transfer radical polymerization. the resultant samples were characterized via nuclear magnetic resonance, fourier transform infrared spectroscopy, transmission electron microscopy, and thermogravimetric analysis. their molecular weights and molecular weight distributions were determined via gel permeation chromatography after the removal of silica by etching. moreover, the phase behavior of these polyzwitterionic-grafted silica nanoparticles in aqueous solutions and stability in protein/pbs solutions were systematically investigated. dynamic light scattering and uv-visible spectroscopy results indicate that the silica-g-psbma nanoparticles exhibit an upper critical solution temperature (ucst) in aqueous solutions, which can be controlled by varying the psbma molecular weight, ionic strength, silica-g-psbma nanoparticle concentration, and solvent polarity. the ucsts shift toward high temperatures with increasing psbma molecular weight and silica-g-psbma nanoparticle concentration. however, increasing the ionic strength and solvent polarity leads to a lowering of the ucsts. the silica-g-psbma nanoparticles are stable for at least 72 h in both negative and positive protein/pbs solutions at 37 degrees c. the current study is crucial for the translation of polyzwitterionic solution behavior to surfaces to exploit their diverse properties in the development of new, smart, and responsive coatings.
收录类别	SCI收录期刊论文
语种	英语
WOS记录号	WOS:000298118500068
公开日期	2012-06-07
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/44166]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Dong ZX,Mao J,Yang MQ,et al. Phase Behavior of Poly(sulfobetaine methacrylate)-Grafted Silica Nanoparticles and Their Stability in Protein Solutions[J]. langmuir,2011,27(24):15282-15291.
APA	Dong ZX,Mao J,Yang MQ,Wang DP,Bo SQ,&Ji XL.(2011).Phase Behavior of Poly(sulfobetaine methacrylate)-Grafted Silica Nanoparticles and Their Stability in Protein Solutions.langmuir,27(24),15282-15291.
MLA	Dong ZX,et al."Phase Behavior of Poly(sulfobetaine methacrylate)-Grafted Silica Nanoparticles and Their Stability in Protein Solutions".langmuir 27.24(2011):15282-15291.