Synthesis of Magnetic, Up-Conversion Luminescent, and Mesoporous Core-Shell-Structured Nanocomposites as Drug Carriers

	Synthesis of Magnetic, Up-Conversion Luminescent, and Mesoporous Core-Shell-Structured Nanocomposites as Drug Carriers
	Gai SL ; Yang PP ; Li CX ; Wang WX ; Dai YL ; Niu N ; Lin J
刊名	advanced functional materials
	2010
卷号	20 期号:7 页码:1166-1172
关键词	RARE-EARTH NANOPHOSPHORS BIOLOGICAL LABELS NANOPARTICLES SILICA DELIVERY FLUORESCENCE SURFACE NANOCRYSTALS FABRICATION PARTICLES
ISSN号	1616-301x
通讯作者	lin j
中文摘要	the synthesis (by a facile two-step sol-gel process), characterization, and application in controlled drug release is reported for monodisperse coreshell-structured fe3o4@nsio(2)@msio(2)@nayf4: yb3+; er3+/tm3+ nanocomposites with mesoporous, up-conversion luminescent, and magnetic properties. the nanocomposites show typical ordered mesoporous characteristics and a monodisperse spherical morphology with narrow size distribution (around 80 nm). in addition, they exhibit high magnetization (38.0 emu g(-1), thus it is possible for drug targeting under a foreign magnetic field) and unique up-conversion emission (green for yb3+/er3+ and blue for yb3+/tm3+) under 980 nm laser excitation even after loading with drug molecules. drug release tests suggest that the multifunctional nanocomposites have a controlled drug release property. interestingly, the up-conversion emission intensity of the multifunctional carrier increases with the released amount of model drug, thus allowing the release process to be monitored and tracked by the change of photoluminescence intensity. this composite can act as a multifunctional drug carrier system, which can realize the targeting and monitoring of drugs simultaneously.
收录类别	SCI收录期刊论文
语种	英语
WOS记录号	WOS:000276775600015
公开日期	2012-06-06
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/43795]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Gai SL,Yang PP,Li CX,et al. Synthesis of Magnetic, Up-Conversion Luminescent, and Mesoporous Core-Shell-Structured Nanocomposites as Drug Carriers[J]. advanced functional materials,2010,20(7):1166-1172.
APA	Gai SL.,Yang PP.,Li CX.,Wang WX.,Dai YL.,...&Lin J.(2010).Synthesis of Magnetic, Up-Conversion Luminescent, and Mesoporous Core-Shell-Structured Nanocomposites as Drug Carriers.advanced functional materials,20(7),1166-1172.
MLA	Gai SL,et al."Synthesis of Magnetic, Up-Conversion Luminescent, and Mesoporous Core-Shell-Structured Nanocomposites as Drug Carriers".advanced functional materials 20.7(2010):1166-1172.