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	In vitro effects of metal ions on lipid peroxidation induced by alcohol in mice liver homogenate
	Li H. R. ; Hou S. F. ; Wang W. Y. ; Yang L. S. ; Li Y. H. ; Tan J.
	2003
关键词	alcohol lipid peroxidation mice liver homogenate metal ions thiobarbituric acid method in vitro
英文摘要	The study is aimed to estimate the effect of different heavy metals such as Hg2+, Cd2+, Mn2+, Cr3+, Ni2+, Se2O32-, As2O3 water solution and combined effects of Hg2+, Mn2+, Cr3+ on lipid peroxidation in mice liver homogenate in vitro. Lipid peroxidation was determined as thiobarbituric acid-reacting materials (TBA). We select five different concentrations of selected ions for experiments. Correlations used to identify the concentration of ions associated with lipid peroxidation. The rate of lipid peroxide formation in mice liver homogenate increased with the gradual addition of alcohol. When alcohol dose was up to 0.5 ml, the rate of lipid peroxide formation was greatest. At tested concentrations, the effects of metal ions on lipid peroxidation induced by alcohol were classified into three groups, and are as follows : (1) simulative, Hg2+. (2) inhibitory, Mn2+, Cr3+, Ni2+, Se2O32-. (3) ambiguous, Cd2+, As2O3 water solution. When Hg2+, Mn2+ and Cr3+ were added to the mice liver homogenate with alcohol at the same time, Hg2+, Mn2+ were the main agents for the rate of alcohol induced lipid peroxidation. The simulative effect of Hg2+ on lipid peroxidation induced by alcohol indicate that alcohol-drinkers will have further health risk when they are exposed in polluted regions than others, and Mn2+, Cr3+, Ni2+, Se2O32- may act as free radical scavengers and preventive remedy for alcoholism in part. Furthermore, analysis of combined effect of Hg2+Mn2+ and Cr3+ provide us a new way to estimate the combined effect of multi-materials.
出处	Journal of Environmental Biology
卷	24
期	4
页	423-428
收录类别	SCI
语种	英语
ISSN号	0254-8704
内容类型	SCI/SSCI论文
源URL	[http://ir.igsnrr.ac.cn/handle/311030/23663]
专题	地理科学与资源研究所_历年回溯文献
推荐引用方式 GB/T 7714	Li H. R.,Hou S. F.,Wang W. Y.,et al. In vitro effects of metal ions on lipid peroxidation induced by alcohol in mice liver homogenate. 2003.

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