Death signal transduction induced by co-immobilized TNF-alpha plus IFN-gamma and the development of polymeric anti-cancer drugs

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	Death signal transduction induced by co-immobilized TNF-alpha plus IFN-gamma and the development of polymeric anti-cancer drugs
	Y. Q. Guan ; Z. B. Li ; J. M. Liu
刊名	Biomaterials
	2010
卷号	31 期号:34 页码:9074-9085
关键词	HeLa Co-immobilized TNF-alpha plus IFN-gamma TNFR1 IFNR2 STAT1 Tyrosine 701 phosphorylation tumor-necrosis-factor nf-kappa-b mesenchymal stem-cells interferon-gamma transcription factors surface modification induced apoptosis factor receptor growth-factor activation
ISSN号	0142-9612
中文摘要	Based on our earlier work on the apoptosis in HeLa cells induced by TNF-alpha plus IFN-gamma, we investigate how the co-immobilized TNF-alpha plus IFN-gamma promotes the signal transduction of HeLa cells. It is found that the free TNF-alpha plus IFN-gamma has much stronger capability than the co-immobilized TNF-alpha plus IFN-gamma in binding with apoptosis signaling receptors TNFR1, which allows an argument that the co-immobilized TNF-alpha plus IFN-gamma can modulate the death pathway of HeLa cells. Subsequently, we determine the cell membrane surface receptor with which the co-immobilized TNF-alpha plus IFN-gamma binds, and probe the expression of death receptor which induces the apoptosis pathway upstream protein FADD and TRADD. Our results reveal that the death signal transduction, induced by the co-immobilized TNF-alpha plus IFN-gamma, is mainly realized via the IFN-gamma signaling pathway rather than the TNF-alpha one. In addition, the transcription of STAT1 plus its Serine 727 and Tyrosine 701 phosphorylation is not the pre-requisite for inducing the cell death signal transduction. It is thus suggested that the co-immobilized TNF-alpha plus IFN-gamma promotes the activation of some unknown key markers in response to IFN-gamma, and the binding of the co-immobilized TNF-alpha plus IFN-gamma with some other TNF-alpha receptors results in enhanced programmed cell death in HeLa cells. (C) 2010 Elsevier Ltd. All rights reserved.
原文出处	://WOS:000283814600029
公开日期	2012-04-13
内容类型	期刊论文
源URL	[http://210.72.142.130/handle/321006/31123]
专题	金属研究所_中国科学院金属研究所
推荐引用方式 GB/T 7714	Y. Q. Guan,Z. B. Li,J. M. Liu. Death signal transduction induced by co-immobilized TNF-alpha plus IFN-gamma and the development of polymeric anti-cancer drugs[J]. Biomaterials,2010,31(34):9074-9085.
APA	Y. Q. Guan,Z. B. Li,&J. M. Liu.(2010).Death signal transduction induced by co-immobilized TNF-alpha plus IFN-gamma and the development of polymeric anti-cancer drugs.Biomaterials,31(34),9074-9085.
MLA	Y. Q. Guan,et al."Death signal transduction induced by co-immobilized TNF-alpha plus IFN-gamma and the development of polymeric anti-cancer drugs".Biomaterials 31.34(2010):9074-9085.