Facile Synthesis of Glycopolypeptides by Combination of Ring-Opening Polymerization of an Alkyne-Substituted N-carboxyanhydride and Click "Glycosylation"

	Facile Synthesis of Glycopolypeptides by Combination of Ring-Opening Polymerization of an Alkyne-Substituted N-carboxyanhydride and Click "Glycosylation"
	Xiao CS ; Zhao CW ; He P ; Tang ZH ; Chen XS ; Jing XB
刊名	macromolecular rapid communications
	2010
卷号	31 期号:11 页码:991-997
关键词	LIVING RADICAL POLYMERIZATION BLOCK-COPOLYMERS ESCHERICHIA-COLI POLYPEPTIDE BACKBONE TRIBLOCK COPOLYMERS CIRCULAR-DICHROISM CHOLERA-TOXIN GLYCOPOLYMERS ACID GLYCOPEPTIDE
ISSN号	1022-1336
通讯作者	chen xs
中文摘要	synthetic glycopolypeptides have attracted much interest for application in biomedical field as they are structural mimics to the natural glycopeptides or glycoproteins. however, the synthesis methods toward glycopolypeptides are still few or less efficient. herein, we present a facile route to preparation of glycopolypeptides with highly effective "glycosylation" by click postpolymerization modification. first, an alkyne-substituted n-carboxyanhydride (nca) monomer was synthesized and subsequently polymerized to afford the polypeptide with "clickable" alkyne pendants. the alkyne-functionalized polypeptide was then "glycosylated" by click reaction of different sugar azides to the alkyne pendants with high efficiency. all the obtained glycopolypeptides were soluble and preferred a-helix conformation in water. primary studies on the obtained glycopolypeptides binding with con a lectin were assessed by turbidimetric assay. the more quantitive studies of the interactions between lectin proteins and the synthetic glycopolypeptides, and the application of these materials as the multivalent ligands are in progress.
收录类别	SCI收录期刊论文
语种	英语
WOS记录号	WOS:000279099300005
公开日期	2012-04-26
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/43636]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Xiao CS,Zhao CW,He P,et al. Facile Synthesis of Glycopolypeptides by Combination of Ring-Opening Polymerization of an Alkyne-Substituted N-carboxyanhydride and Click "Glycosylation"[J]. macromolecular rapid communications,2010,31(11):991-997.
APA	Xiao CS,Zhao CW,He P,Tang ZH,Chen XS,&Jing XB.(2010).Facile Synthesis of Glycopolypeptides by Combination of Ring-Opening Polymerization of an Alkyne-Substituted N-carboxyanhydride and Click "Glycosylation".macromolecular rapid communications,31(11),991-997.
MLA	Xiao CS,et al."Facile Synthesis of Glycopolypeptides by Combination of Ring-Opening Polymerization of an Alkyne-Substituted N-carboxyanhydride and Click "Glycosylation"".macromolecular rapid communications 31.11(2010):991-997.