Biodegradable Block Copolymer-Doxorubicin Conjugates via Different Linkages: Preparation, Characterization, and In Vitro Evaluation | |
Hu XL ; Liu S ; Huang YB ; Chen XS ; Jing XB | |
刊名 | biomacromolecules |
2010 | |
卷号 | 11期号:8页码:2094-2102 |
关键词 | POLYMERIC MICELLES TARGETED DELIVERY DRUG CARRIERS SOLID TUMORS CELL-LINE NANOPARTICLES SYSTEM BLOOD |
ISSN号 | 1525-7797 |
通讯作者 | jing xb |
中文摘要 | doxorubicin (dox) was conjugated onto a biodegradable block copolymer methoxy-poly(ethylene glycol)-block-poly(lactide-co-2,2-dihydroxymethylpropylene carbonate (mpeg-b-p(la-co-dhp)) via a carbamate linkage and an acid-labile hydrazone linkage, respectively. mutifunctional mixed micelles consisting of dox-containing copolymer mpeg-b-p(la-co-dhp/dox) and folic acid-containing copolymer mpeg-b-p(la-co-dhp/fa) were successfully prepared by coassembling the two component copolymers. the mixed micelles had well-defined core shell structure and their diameters were in the range of 70-100 nm. both dox-conjugates (via carbamate or hydrazone linkage) showed ph-dependent release behavior, and the micelles with hydrazone linkage showed more ph-sensitivity compared to those with carbamate linkage. the in vitro cell uptake experiment by clsm and flow cytometry showed preferential internalization of fa-containing micelles by human ovarian cancer cell line skov-3 than that without fa. flow cytometric analysis was conducted to reveal the enhanced cell apoptosis caused by the fa-containing micelles. these results suggested that these micelles containing both chemotherapeutic and targeting ligand could be a promising nanocarrier for targeting the drugs to cancer cells and releasing the drug molecules inside the cancer cells. |
收录类别 | SCI收录期刊论文 |
语种 | 英语 |
WOS记录号 | WOS:000280583400026 |
公开日期 | 2012-04-26 |
内容类型 | 期刊论文 |
源URL | [http://ir.ciac.jl.cn/handle/322003/43559] |
专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
推荐引用方式 GB/T 7714 | Hu XL,Liu S,Huang YB,et al. Biodegradable Block Copolymer-Doxorubicin Conjugates via Different Linkages: Preparation, Characterization, and In Vitro Evaluation[J]. biomacromolecules,2010,11(8):2094-2102. |
APA | Hu XL,Liu S,Huang YB,Chen XS,&Jing XB.(2010).Biodegradable Block Copolymer-Doxorubicin Conjugates via Different Linkages: Preparation, Characterization, and In Vitro Evaluation.biomacromolecules,11(8),2094-2102. |
MLA | Hu XL,et al."Biodegradable Block Copolymer-Doxorubicin Conjugates via Different Linkages: Preparation, Characterization, and In Vitro Evaluation".biomacromolecules 11.8(2010):2094-2102. |
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