Toxicological study of injuries of rat's hippocampus after lead poisoning by synchrotron microradiography and elemental mapping

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	Toxicological study of injuries of rat's hippocampus after lead poisoning by synchrotron microradiography and elemental mapping
	Liang, F ; Zhang, GL ; Xiao, XH ; Cai, ZH ; Lai, B ; Hwu, Y ; Yan, CH ; Xu, JA ; Li, YL ; Tan, MG ; Zhang, CF ; Li, Y
刊名	NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS
	2010
卷号	268 期号:17-18 页码:6
关键词	Hippocampus Lead Phase contrast X-ray imaging Micro-beam X-ray fluorescence Synchrotron radiation
ISSN号	0168-583X
通讯作者	Zhang, GL (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China
英文摘要	The hippocampus, a major component of the brain, is one of the target nervous organs in lead poisoning In this work, a rat's hippocampal injury caused by lead was studied. The lead concentrations in blood, bone and hippocampus collected from rats subject to lead poisoning were quantified by Inductively Coupled Plasma Mass Spectrometry while morphological information and elemental distributions in the hippocampus were obtained with synchrotron radiation X-ray phase contrast imaging and synchrotron radiation micro-beam X-ray fluorescence, respectively For comparison, identical characterization of the specimens from the rats in the control group was done in parallel Results show that the ratios between the lead content in the treated group and that in the control group of the hippocampus, bone, and blood are about 2 66, 236, and 39 6, respectively Analysis also revealed that some health elements such as S. K. Cl and P increase in the regions with high lead content in the treated hippocampus Morphological differences between the normal and lead-exposed hippocampus specimens in some local areas were observed. Explicitly, the structure of the lead-exposed hippocampus was tortuous and irregular, and the density of the neurons in the Dentate Gyrus was significantly lower than that from the control group The study shows that the synchrotron radiation methods are very powerful for investigating structural injury caused by heavy metals in the nervous system. (C) 2010 Elsevier B V All rights reserved
学科主题	Instruments & Instrumentation; Nuclear Science & Technology; Physics
收录类别	SCI
语种	英语
WOS记录号	WOS:000281498900047
公开日期	2012-04-11
内容类型	期刊论文
源URL	[http://ir.sinap.ac.cn/handle/331007/7099]
专题	上海应用物理研究所_中科院上海应用物理研究所2004-2010年
推荐引用方式 GB/T 7714	Liang, F,Zhang, GL,Xiao, XH,et al. Toxicological study of injuries of rat's hippocampus after lead poisoning by synchrotron microradiography and elemental mapping[J]. NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS,2010,268(17-18):6.
APA	Liang, F.,Zhang, GL.,Xiao, XH.,Cai, ZH.,Lai, B.,...&Li, Y.(2010).Toxicological study of injuries of rat's hippocampus after lead poisoning by synchrotron microradiography and elemental mapping.NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS,268(17-18),6.
MLA	Liang, F,et al."Toxicological study of injuries of rat's hippocampus after lead poisoning by synchrotron microradiography and elemental mapping".NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS 268.17-18(2010):6.