Design, synthesis, and evaluation of cyclofenil derivatives for potential SPECT imaging agents

CORC > 上海应用物理研究所 > 中国科学院上海应用物理研究所 > 中科院上海应用物理研究所2004-2010年

	Design, synthesis, and evaluation of cyclofenil derivatives for potential SPECT imaging agents
	Zhu, H ; Huang, LL ; Zhang, YQ ; Xu, XP ; Sun, YH ; Shen, YM
刊名	JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
	2010
卷号	15 期号:4 页码:9
关键词	Cyclofenil Tricarbonyl rhenium Radiolabeling Nonsteroidal Estrogen receptor
ISSN号	0949-8257
通讯作者	Shen, YM (reprint author), Shanghai Jiao Tong Univ, Shanghai Ctr Syst Biomed, 800 Dongchuan Rd, Shanghai 200240, Peoples R China
英文摘要	To develop technetium- and rhenium-labeled nonsteroidal estrogen imaging agents for estrogen receptor (ER) positive breast tumors, two groups of rhenium and technetium cyclofenil derivatives were synthesized and characterized. The binding affinities of the rhenium complexes for ERs were determined. The tricarbonyl rhenium complex showed the highest binding affinity for ERs (81.2 for ER beta, 16.5 for ER alpha). Tricarbonyl technetium cyclofenil complexes were obtained in high radiochemical purity and radiochemical yields. The results of studies of their octanol/water partition and in vitro stability are presented. These results demonstrate that these radiolabeled cyclofenil derivatives may be considered as potential breast cancer imaging agents.
学科主题	Biochemistry & Molecular Biology; Chemistry
收录类别	SCI
语种	英语
WOS记录号	WOS:000276660400011
公开日期	2012-04-11
内容类型	期刊论文
源URL	[http://ir.sinap.ac.cn/handle/331007/6881]
专题	上海应用物理研究所_中科院上海应用物理研究所2004-2010年
推荐引用方式 GB/T 7714	Zhu, H,Huang, LL,Zhang, YQ,et al. Design, synthesis, and evaluation of cyclofenil derivatives for potential SPECT imaging agents[J]. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY,2010,15(4):9.
APA	Zhu, H,Huang, LL,Zhang, YQ,Xu, XP,Sun, YH,&Shen, YM.(2010).Design, synthesis, and evaluation of cyclofenil derivatives for potential SPECT imaging agents.JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY,15(4),9.
MLA	Zhu, H,et al."Design, synthesis, and evaluation of cyclofenil derivatives for potential SPECT imaging agents".JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY 15.4(2010):9.