Fine tuning by human CD1e of lipid-specific immune responses

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Fine tuning by human CD1e of lipid-specific immune responses
	Facciotti, Federica 1; Cavallari, Marco 1; Angenieux, Catherine 2,3; Garcia-Alles, Luis F.4; Signorino-Gelo, Francois 2,3; Angman, Lena 1; Gilleron, Martine 4; Prandi, Jacques 4; Puzo, Germain 4; Panza, Luigi 5
刊名	PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
	2011-08-23
卷号	108 期号:34 页码:14228-14233
关键词	CD1 restriction lipid transfer proteins natural killer T cells
ISSN号	0027-8424
通讯作者	Mori, L (reprint author), Univ Basel Hosp, Dept Biomed, CH-4031 Basel, Switzerland
英文摘要	CD1e is a member of the CD1 family that participates in lipid antigen presentation without interacting with the T-cell receptor. It binds lipids in lysosomes and facilitates processing of complex glycolipids, thus promoting editing of lipid antigens. We find that CD1e may positively or negatively affect lipid presentation by CD1b, CD1c, and CD1d. This effect is caused by the capacity of CD1e to facilitate rapid formation of CD1-lipid complexes, as shown for CD1d, and also to accelerate their turnover. Similar results were obtained with antigen-presenting cells from CD1e transgenic mice in which lipid complexes are assembled more efficiently and show faster turnover than in WT antigen-presenting cells. These effects maximize and temporally narrow CD1-restricted responses, as shown by reactivity to Sphingomonas paucimobilis-derived lipid antigens. CD1e is therefore an important modulator of both group 1 and group 2 CD1-restricted responses influencing the lipid antigen availability as well as the generation and persistence of CD1-lipid complexes.
学科主题	Science & Technology - Other Topics
类目[WOS]	Multidisciplinary Sciences
研究领域[WOS]	Science & Technology - Other Topics
关键词[WOS]	KILLER T-CELLS ; MYCOBACTERIUM-TUBERCULOSIS ; ANTIGEN PRESENTATION ; DENDRITIC CELLS ; MOUSE CD1D ; NKT CELLS ; MOLECULES ; PATHWAY ; RECOGNITION ; ACTIVATION
收录类别	SCI
资助信息	Swiss National Science Foundation[3100A0 122464/1]; European Union; University Hospital Basel; French National Research Agency[ANR-05-MIIM-006]; Etablissement Francais du Sang-Alsace
语种	英语
WOS记录号	WOS:000294163500072
公开日期	2012-04-10
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/5549]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Univ Basel Hosp, Dept Biomed, CH-4031 Basel, Switzerland 2.Univ Strasbourg, INSERM, UMR S725, F-67065 Strasbourg, France 3.Etab Francais Sang Alsace, F-67065 Strasbourg, France 4.CNRS, Inst Pharmacol & Biol Struct, F-31077 Toulouse, France 5.Univ Piemonte Orientale, Dept Chem Food Pharmaceut & Pharmacol, I-28100 Novara, Italy 6.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China 7.Ohio State Univ, Dept Biochem & Chem, Columbus, OH 43210 USA 8.Ist Sci San Raffaele, Expt Immunol Unit, Div Immunol Transplantat & Infect Dis, Dipartimento Biotecnol DIBIT, I-20132 Milan, Italy 9.Albert Einstein Coll Med, Bronx, NY 10461 USA 10.Agcy Sci Technol & Res, Singapore Immunol Network, Singapore 138648, Singapore
推荐引用方式 GB/T 7714	Facciotti, Federica,Cavallari, Marco,Angenieux, Catherine,et al. Fine tuning by human CD1e of lipid-specific immune responses[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2011,108(34):14228-14233.
APA	Facciotti, Federica.,Cavallari, Marco.,Angenieux, Catherine.,Garcia-Alles, Luis F..,Signorino-Gelo, Francois.,...&De Libero, Gennaro.(2011).Fine tuning by human CD1e of lipid-specific immune responses.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,108(34),14228-14233.
MLA	Facciotti, Federica,et al."Fine tuning by human CD1e of lipid-specific immune responses".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 108.34(2011):14228-14233.