Two dimeric lignans with an unusual alpha,beta-unsaturated ketone motif from Zanthoxylum podocarpum and their inhibitory effects on nitric oxide production

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	Two dimeric lignans with an unusual alpha,beta-unsaturated ketone motif from Zanthoxylum podocarpum and their inhibitory effects on nitric oxide production
	Zhou, Xiao-Jiang 1,2; Chen, Xiao-Liang 1; Li, Xue-Song 1,2; Su, Jia 1; He, Jiang-Bo 1; Wang, Yue-Hu1 ; Li, Yan1 ; Cheng, Yong-Xian 1
刊名	BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
	2011
卷号	21 期号:1 页码:373-376
关键词	Zanthoxylum podocarpum Rutaceae Dimeric lignans Zanthpodocarpins A and B Nitric oxide production
ISSN号	0960-894X
通讯作者	Cheng, YX (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
英文摘要	Two new dimeric lignans, zanthpodocarpins A (1) and B (2), and five known lignans, eudesmin (3), (1R,2R,5R,6S)-2-(3,4-dimethoxyphenyl)-6-(3,4-dihydroxyphenyl)-3,7-dioxabicyclo[3.3.0]octane (4), dimethoxysamin (5), rel-(1R,5R,6S)-6-(4-hydroxy-3-methoxyphenyl)-3,7-dioxabicyclo[ 3.3.0]octan-2-one (6), and magnone A (7), were isolated from the barks of Zanthoxylum podocarpum. Their structures were identified by using spectroscopic methods. Compounds 1 and 2 are rare dilignans bearing an unusual alpha,beta-unsaturated ketone group from a natural source. Bioassay showed that compounds 1 and 2 could inhibit nitric oxide (NO) production in LPS stimulated RAW 264.7 cells with IC(50) values of 5.31 mu M and 12.15 mu M, respectively. (c) 2010 Elsevier Ltd. All rights reserved.
学科主题	Pharmacology & Pharmacy; Chemistry
类目[WOS]	Chemistry, Medicinal ; Chemistry, Organic
研究领域[WOS]	Pharmacology & Pharmacy ; Chemistry
收录类别	SCI
资助信息	'Talent Scholarship of Yunnan Youth' from Yunnan Province[2007PY01-48]; Ministry of Science and Technology of China[2008ZX09401-004, 2009CB522300]
语种	英语
WOS记录号	WOS:000285544400076
公开日期	2012-04-10
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/5529]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 2.Hunan Univ Chinese Med, Coll Pharm, Changsha 410208, Hunan, Peoples R China
推荐引用方式 GB/T 7714	Zhou, Xiao-Jiang,Chen, Xiao-Liang,Li, Xue-Song,et al. Two dimeric lignans with an unusual alpha,beta-unsaturated ketone motif from Zanthoxylum podocarpum and their inhibitory effects on nitric oxide production[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2011,21(1):373-376.
APA	Zhou, Xiao-Jiang.,Chen, Xiao-Liang.,Li, Xue-Song.,Su, Jia.,He, Jiang-Bo.,...&Cheng, Yong-Xian.(2011).Two dimeric lignans with an unusual alpha,beta-unsaturated ketone motif from Zanthoxylum podocarpum and their inhibitory effects on nitric oxide production.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,21(1),373-376.
MLA	Zhou, Xiao-Jiang,et al."Two dimeric lignans with an unusual alpha,beta-unsaturated ketone motif from Zanthoxylum podocarpum and their inhibitory effects on nitric oxide production".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 21.1(2011):373-376.