Diabetic nephropathy-related active cyclic peptides from the roots of Brachystemma calycinum

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Diabetic nephropathy-related active cyclic peptides from the roots of Brachystemma calycinum
	Cheng, Yong-Xian 1; Zhou, Li-Li 2; Yan, Yong-Ming 1; Chen, Ke-Xin 1; Hou, Fan-Fan 2
刊名	BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
	2011-12-15
卷号	21 期号:24 页码:7434-7439
关键词	Brachystemma calycinum Caryophyllaceae Cyclic peptides Cytokines Collagen IV ROS
ISSN号	0960-894X
通讯作者	Cheng, YX (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
英文摘要	Three new cyclic peptides, namely duanbanhuains A-C (1-3), were isolated from the roots of Brachystemma calycinum which is a traditional medicine used to treat rheumatic diseases. Their structures were identified by means of a suite of MS and NMR experiments. These compounds were purposely evaluated for their inhibitory effects on the release of MCP-1, IL-6, collagen IV and reactive oxygen species (ROS) against high-glucose-stimulated mesangial cells. The results showed that compounds 1 and 2 exhibited potent inhibition on the production of IL-6, collagen IV and ROS at the concentration of 10 mu M. (C) 2011 Elsevier Ltd. All rights reserved.
学科主题	Pharmacology & Pharmacy; Chemistry
类目[WOS]	Chemistry, Medicinal ; Chemistry, Organic
研究领域[WOS]	Pharmacology & Pharmacy ; Chemistry
关键词[WOS]	IDENTIFICATION ; CYCLOPEPTIDES ; EXPRESSION ; GLUCOSE ; CELLS
收录类别	SCI
资助信息	National Natural Science Foundation of China[30700059]; Talent Scholarship of Yunnan Youth[2007PY01-48]; Chinese Academy of Sciences[KSCX2-EW-R-15]
语种	英语
WOS记录号	WOS:000297150600039
公开日期	2012-04-10
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/5525]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 2.So Med Univ, Nanfang Hosp, Div Nephrol, Key Lab Organ Failure Res,Educ Minist, Guangzhou 510515, Guangdong, Peoples R China
推荐引用方式 GB/T 7714	Cheng, Yong-Xian,Zhou, Li-Li,Yan, Yong-Ming,et al. Diabetic nephropathy-related active cyclic peptides from the roots of Brachystemma calycinum[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2011,21(24):7434-7439.
APA	Cheng, Yong-Xian,Zhou, Li-Li,Yan, Yong-Ming,Chen, Ke-Xin,&Hou, Fan-Fan.(2011).Diabetic nephropathy-related active cyclic peptides from the roots of Brachystemma calycinum.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,21(24),7434-7439.
MLA	Cheng, Yong-Xian,et al."Diabetic nephropathy-related active cyclic peptides from the roots of Brachystemma calycinum".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 21.24(2011):7434-7439.