Cell entry of one-dimensional nanomaterials occurs by tip recognition and rotation

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	Cell entry of one-dimensional nanomaterials occurs by tip recognition and rotation
	Shi XH(施兴华); von dem Bussche A; Hurt RH; Kane AB; Gao HJ(高华健)
刊名	Nature Nanotechnology
	2011
通讯作者邮箱	Agnes_Kane@brown.edu; Huajian_Gao@brown.edu
卷号	6 期号:11 页码:714-719
关键词	Walled Carbon Nanotubes Receptor-Mediated Endocytosis Asbestos Phagocytosis Nanoparticles Toxicity Inflammation Macrophages Crocidolite Responses
ISSN号	1748-3387
通讯作者	Shi, XH (reprint author), Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech, Beijing 100190, Peoples R China
产权排序	[von dem Bussche, Annette; Kane, Agnes B] Brown Univ, Dept Pathol & Lab Med, Providence, RI 02912 USA; [Shi, Xinghua; Hurt, Robert H; Gao, Huajian] Brown Univ, Sch Engn, Providence, RI 02912 USA; [Hurt, Robert H; Kane, Agnes B; Gao, Huajian] Brown Univ, Inst Mol & Nanoscale Innovat, Providence, RI 02912 USA
合作状况	国际
中文摘要	Materials with high aspect ratio, such as carbon nanotubes and asbestos fibres, have been shown to cause length-dependent toxicity in certain cells because these long materials prevent complete ingestion and this frustrates the cell(1-3). Biophysical models have been proposed to explain how spheres and elliptical nanostructures enter cells(4-8), but one-dimensional nanomaterials have not been examined. Here, we show experimentally and theoretically that cylindrical one-dimensional nanomaterials such as carbon nanotubes enter cells through the tip first. For nanotubes with end caps or carbon shells at their tips, uptake involves tip recognition through receptor binding, rotation that is driven by asymmetric elastic strain at the tube-bilayer interface, and near-vertical entry. The precise angle of entry is governed by the relative timescales for tube rotation and receptor diffusion. Nanotubes without caps or shells on their tips show a different mode of membrane interaction, posing an interesting question as to whether modifying the tips of tubes may help avoid frustrated uptake by cells.
学科主题	Science & Technology - Other Topics; Materials Science
分类号	一类
类目[WOS]	Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
研究领域[WOS]	Science & Technology - Other Topics ; Materials Science
关键词[WOS]	WALLED CARBON NANOTUBES ; RECEPTOR-MEDIATED ENDOCYTOSIS ; ASBESTOS ; PHAGOCYTOSIS ; NANOPARTICLES ; TOXICITY ; INFLAMMATION ; MACROPHAGES ; CROCIDOLITE ; RESPONSES
收录类别	SCI
资助信息	This work was supported by the National Science Foundation (NSF; grant CMMI-1028530), the US Department of Commerce, National Institute of Standards and Technology as part of the Rhode Island Consortium for Nanoscience and Nanotechnology, the National Institute of Environmental Health Sciences (NIEHS) Superfund Research Program P42 ES013660, and an R01 grant (ES016178) from the NIEHS. The simulations reported were performed on NSF TeraGrid resources provided by National Institute for Computational Sciences (NICS; under MCB090194) and resources from the Supercomputing Center of Chinese Academy of Sciences (SCCAS) and Shanghai Supercomputer Center (SSC). The authors thank P. Weston in the Molecular Pathology Core at Brown University for her assistance with electron microscopic sample preparation and imaging and F. Guo for measurement of MWCNT zeta potentials.
原文出处	http://dx.doi.org/10.1038/NNANO.2011.151
语种	英语
WOS记录号	WOS:000296737300009
公开日期	2012-04-01
内容类型	期刊论文
源URL	[http://dspace.imech.ac.cn/handle/311007/44897]
专题	力学研究所_非线性力学国家重点实验室
推荐引用方式 GB/T 7714	Shi XH,von dem Bussche A,Hurt RH,et al. Cell entry of one-dimensional nanomaterials occurs by tip recognition and rotation[J]. Nature Nanotechnology,2011,6(11):714-719.
APA	施兴华,von dem Bussche A,Hurt RH,Kane AB,&高华健.(2011).Cell entry of one-dimensional nanomaterials occurs by tip recognition and rotation.Nature Nanotechnology,6(11),714-719.
MLA	施兴华,et al."Cell entry of one-dimensional nanomaterials occurs by tip recognition and rotation".Nature Nanotechnology 6.11(2011):714-719.