Mutation spectrum in Salmonella induced by environmental tobacco smoke | |
Zhou, RQ ; Yu, G ; Zhou, YQ ; Zeng, XF | |
刊名 | ENVIRONMENTAL AND MOLECULAR MUTAGENESIS |
1999 | |
卷号 | 33期号:3页码:185-193 |
关键词 | environmental tobacco smoke mutation spectrum Ames/Salmonella |
ISSN号 | 0893-6692 |
通讯作者 | Zhou, RQ, Liaoning Univ, Dept Biol, Shenyang 110036, Liaoning Prov, Peoples R China |
中文摘要 | Environmental tobacco smoke (ETS) is a major source of indoor air pollution. Extractable-respirable particulate (ERP) from the ETS-contaminated indoor air (ERP-ETS) was collected from six passenger train cars and one control room. The mutagenicity of ERP-ETS was tested in the Ames/Salmonella test in the presence of male rat liver microsomal Fraction S9. The mutation spectrum of ERP-ETS was determined by colony probe hybridization and polymerase chain reaction/DNA sequence analysis in approximately 2,370 His(+) revertants. The results indicate that the majority of ERP-ETS-induced mutations were a two-base deletion of GC or CG within the hotspot sequence of CGCGCGCG at the frameshift hisD3052 allele in strain TA98, The ERP-ETS From the control room induced approximately 94.3% such deletions, while the ERP-ETS collected From the passenger cars induced approximately 89.6% such deletions. The ERP-ETS either from the control room or from the passenger cars induced approximately 74%C/G --> A/T transversions, and approximately 23% C/G --> T/A transitions within the primary target CCC at the hisG46 allele in strain TA100. (C) 1999 Wiley-Liss, Inc. |
学科主题 | Environmental Sciences; Genetics & Heredity; Toxicology |
收录类别 | SCI |
语种 | 英语 |
公开日期 | 2011-09-23 |
内容类型 | 期刊论文 |
源URL | [http://210.72.129.5/handle/321005/55613] |
专题 | 沈阳应用生态研究所_沈阳应用生态研究所_期刊论文 |
推荐引用方式 GB/T 7714 | Zhou, RQ,Yu, G,Zhou, YQ,et al. Mutation spectrum in Salmonella induced by environmental tobacco smoke[J]. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS,1999,33(3):185-193. |
APA | Zhou, RQ,Yu, G,Zhou, YQ,&Zeng, XF.(1999).Mutation spectrum in Salmonella induced by environmental tobacco smoke.ENVIRONMENTAL AND MOLECULAR MUTAGENESIS,33(3),185-193. |
MLA | Zhou, RQ,et al."Mutation spectrum in Salmonella induced by environmental tobacco smoke".ENVIRONMENTAL AND MOLECULAR MUTAGENESIS 33.3(1999):185-193. |
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