| Multipotent AChE and BACE-1 inhibitors for the treatment of Alzheimer's disease: Design, synthesis and bio-analysis of 7-amino-1,4-dihydro-2H-isoquilin-3-one derivates | |
| Zhao, Xiong-jie; Gong, Da-min; Jiang, Yu-ren*; Guo, Dong; Zhu, Yao; Deng, You-chao | |
| 刊名 | European Journal of Medicinal Chemistry
 |
| 2017 | |
| 卷号 | 138页码:738-747 |
| 关键词 | Alzheimer's disease Acetylcholinesterase β-secretase Metal chelators Inhibitor AChE acetylcholinesterase AChEIs acetylcholinesterase inhibitors Aβ β-amyloid AD Alzheimer's disease PAS peripheral anionic sites BACE-1 β-secretase MTDLs multi-target-directed ligands PDB Protein Data Bank TLC thin layer chromatography |
| ISSN号 | 0223-5234 |
| DOI | 10.1016/j.ejmech.2017.07.006 |
| URL标识 | 查看原文 |
| WOS记录号 | WOS:000411297000058 |
| 内容类型 | 期刊论文 |
| URI标识 | http://www.corc.org.cn/handle/1471x/3345880 |
| 专题 | 中南大学 |
| 作者单位 | 1.[Gong, Da-min 2.Zhao, Xiong-jie 3.Deng, You-chao 4.Jiang, Yu-ren 5.Zhu, Yao 6.Guo, Dong] Cent S Univ, Dept Pharmaceut Engn, Coll Chem & Chem Engn, Changsha 410083, Hunan, Peoples R China. |
| 推荐引用方式 GB/T 7714 | Zhao, Xiong-jie,Gong, Da-min,Jiang, Yu-ren*,et al. Multipotent AChE and BACE-1 inhibitors for the treatment of Alzheimer's disease: Design, synthesis and bio-analysis of 7-amino-1,4-dihydro-2H-isoquilin-3-one derivates[J]. European Journal of Medicinal Chemistry,2017,138:738-747. |
| APA | Zhao, Xiong-jie,Gong, Da-min,Jiang, Yu-ren*,Guo, Dong,Zhu, Yao,&Deng, You-chao.(2017).Multipotent AChE and BACE-1 inhibitors for the treatment of Alzheimer's disease: Design, synthesis and bio-analysis of 7-amino-1,4-dihydro-2H-isoquilin-3-one derivates.European Journal of Medicinal Chemistry,138,738-747. |
| MLA | Zhao, Xiong-jie,et al."Multipotent AChE and BACE-1 inhibitors for the treatment of Alzheimer's disease: Design, synthesis and bio-analysis of 7-amino-1,4-dihydro-2H-isoquilin-3-one derivates".European Journal of Medicinal Chemistry 138(2017):738-747. |
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