Simultaneous Detection of Adenosine Triphosphate and Glucose Based on the Cu-Fenton Reaction

	Simultaneous Detection of Adenosine Triphosphate and Glucose Based on the Cu-Fenton Reaction
	Qu, Fei; Li, Jingwen; Han, Wenli; Xia, Lian; You, Jinmao
刊名	SENSORS
	2018
卷号	18 期号:7
关键词	simultaneous detection Cu-Fenton reaction carbon nanodots adenosine triphosphate glucose satisfactory recoveries
英文摘要	Both adenosine triphosphate (ATP) and glucose are important to human health, and their abnormal levels are closely related to angiocardiopathy and hypoglycaemia. Therefore, the simultaneous determination of ATP and glucose with a single test mode is highly desirable for disease diagnostics and early recognition. Herein, a new fluorescence on/off switch sensing platform is developed by carbon nanodots (CNDs) to detect ATP and glucose simultaneously. The fluorescence of CNDs can be quenched by Cu2+ and hydrogen peroxide (H2O2), due to the formation of hydroxyl radicals (center dot OH) produced in the Cu-Fenton reaction. Based on the high affinity of Cu2+ with ATP, the fluorescence of CNDs will recover effectively after adding ATP. Additionally, glucose can be efficiently catalyzed by glucose oxidase (GOx) to generate H2O2, so the platform can also be utilized to analyze glucose. Under optimum conditions, this sensing platform displays excellent sensitivity and the linear ranges are from 0.1 to 7 mu M for ATP with a limit of detection (LOD) of 30.2 nM, and from 0.1 to 7 mM for glucose with a LOD 39.8 mu M, respectively. Benefiting from the high sensitivity and selectivity, this sensing platform is successfully applied for simultaneous detection of ATP and glucose in human serum samples with satisfactory recoveries.
内容类型	期刊论文
源URL	[http://210.75.249.4/handle/363003/60006]
专题	西北高原生物研究所_中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Qu, Fei,Li, Jingwen,Han, Wenli,et al. Simultaneous Detection of Adenosine Triphosphate and Glucose Based on the Cu-Fenton Reaction[J]. SENSORS,2018,18(7).
APA	Qu, Fei,Li, Jingwen,Han, Wenli,Xia, Lian,&You, Jinmao.(2018).Simultaneous Detection of Adenosine Triphosphate and Glucose Based on the Cu-Fenton Reaction.SENSORS,18(7).
MLA	Qu, Fei,et al."Simultaneous Detection of Adenosine Triphosphate and Glucose Based on the Cu-Fenton Reaction".SENSORS 18.7(2018).