Off-On based fluorescent chemosensor for Cu(2+) in aqueous media and living cells

CORC > 烟台海岸带研究所 > 中国科学院烟台海岸带研究所 > 山东省海岸带环境工程技术研究中心

	Off-On based fluorescent chemosensor for Cu(2+) in aqueous media and living cells
	Yu, Chunwei ; Chen, Lingxin ; Zhang, Jun ; Li, Jinhua ; Liu, Ping ; Wang, Wenhai ; Yan, Bing
刊名	TALANTA
	2011
卷号	85 期号:3 页码:1627-1633
关键词	Cu(2+) Fluorescent chemosensor Rhodamine B Fluorescence imaging Living cells
ISSN号	0039-9140
通讯作者	Chen, LX, Chinese Acad Sci, Key Lab Coastal Zone Environm Proc, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China. lxchen@yic.ac.cn ; dr.bingyan@gmail.com
中文摘要	A novel Cu(2+)-specific "off-on" fluorescent chemosensor of naphthalimide modified rhodamine B (naphthalimide modified rhodamine B chemosensor, NRC) was designed and synthesized, based on the equilibrium between the spirolactam (non-fluorescence) and the ring-opened amide (fluorescence). The chemosensor NRC showed high Cu(2+)-selective fluorescence enhancement over commonly coexistent metal ions or anions in neutral aqueous media. The limit of detection (LOD) based on 3 x delta(blank)/k was obtained as low as 0.18 mu M of Cu(2+), as well as an excellent linearity of 0.05-4.5 mu M (R=0.999), indicating the chemosensor of high sensitivity and wide quantitation range. And also the coordination mode with 1:1 stoichiometry was proposed between NRC and Cu(2+). In addition, the effects of pH, co-existing metal ions and anions, and the reversibility were investigated in detail. It was also demonstrated that the NRC could be used as an excellent "off-on" fluorescent chemosensor for the measurement of Cu(2+) in living cells with satisfying results, which further displayed its valuable applications in biological systems. (C) 2011 Elsevier B.V. All rights reserved.
学科主题	Chemistry
收录类别	SCI
资助信息	National Natural Science Foundation of China[20975089, 90913006, 21077068]; Chinese Academy of Sciences[KZCX2-EW-206]; National Basic Research Program of China[2010CB933504]; Department of Science and Technology of Shandong Province[2008GG20005005]; Research and Training Foundation of Hainan Medical University[HY2010-004]
语种	英语
公开日期	2011-11-11
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/5105]
专题	烟台海岸带研究所_山东省海岸带环境工程技术研究中心烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室
推荐引用方式 GB/T 7714	Yu, Chunwei,Chen, Lingxin,Zhang, Jun,et al. Off-On based fluorescent chemosensor for Cu(2+) in aqueous media and living cells[J]. TALANTA,2011,85(3):1627-1633.
APA	Yu, Chunwei.,Chen, Lingxin.,Zhang, Jun.,Li, Jinhua.,Liu, Ping.,...&Yan, Bing.(2011).Off-On based fluorescent chemosensor for Cu(2+) in aqueous media and living cells.TALANTA,85(3),1627-1633.
MLA	Yu, Chunwei,et al."Off-On based fluorescent chemosensor for Cu(2+) in aqueous media and living cells".TALANTA 85.3(2011):1627-1633.