September March mean temperature has been reconstructed to A.D. 1680 for the Kaiduhe River watershed on the southern slope of the Tien Shan Mountains, China, using the Picea schrenkiana tree-ring width. The reconstruction explains the variance of 47% in the observed mean temperature from 1953 to 2011. Power spectral and wavelet analyses demonstrated the existence of significant 50-year and 2- to 7-year cycles of variability. The results of the spatial correlations suggest that our reconstruction contains climatic signals for Central Asia. Warm periods occurred during 1696-1708, 1730-1748, 1784-1804, 1832-1855, 1892-1903, 1924-1928, 1937-1943, and 1987-2006; while the periods of 1685-1695,1709-1729,1749-1783,1805-1831,1856-1891,1904-1923,1929-1936, and 1944-1986 were relatively cold. The significant correlation coefficient between the reconstruction and the temperature reconstruction for the Urumqi River source reveals that the temperature variations in the annual cold period for the southern and the northern slope of the central Tien Shan Mountains are roughly synchronous over the last nearly 300 years. A comparison between the reconstruction and three winter North Atlantic Oscillation indexes revealed similar long-term trends.