Comprehensive identification of peptides in tandem mass spectra using an efficient open search engine

doi:10.1038/nbt.4236

CORC > 计算技术研究所 > 中国科学院计算技术研究所 > 中国科学院计算技术研究所期刊论文 > 英文

	Comprehensive identification of peptides in tandem mass spectra using an efficient open search engine
	Niu, Xiu-Nan 5,6; Chi, Hao 5,6; Liu, Chao 5,6; Yang, Hao 5,6; Zeng, Wen-Feng 5,6; Wu, Long 5,6; Zhou, Wen-Jing 5,6; Wang, Rui-Min 5,6; Ding, Yue-He 4; Zhang, Yao 1,2,3
刊名	NATURE BIOTECHNOLOGY
	2018-11-01
卷号	36 期号:11 页码:1059-+
ISSN号	1087-0156
DOI	10.1038/nbt.4236
英文摘要	We present a sequence-tag-based search engine, Open-pFind, to identify peptides in an ultra-large search space that includes coeluting peptides, unexpected modifications and digestions. Our method detects peptides with higher precision and speed than seven other search engines. Open-pFind identified 70-85% of the tandem mass spectra in four large-scale datasets and 14,064 proteins, each supported by at least two protein-unique peptides, in a human proteome dataset.
资助项目	National Key Research and Development Program of China[2016YFA0501300] ; National Key Research and Development Program of China[2017YFA0505100] ; National Key Research and Development Program of China[2017YFC0906600] ; National Key Research and Development Program of China[2012CB316502] ; Youth Innovation Promotion Association CAS[2014091] ; National Natural Science Foundation of China[31470805] ; National Natural Science Foundation of China[31670834] ; National Natural Science Foundation of China[31700727] ; National Natural Science Foundation of China[21475141] ; CAS Interdisciplinary Innovation Team[Y604061000] ; International Collaboration Program[2014DFB30020] ; Beijing Training Project for The Leading Talents in ST[Z161100004916024]
WOS研究方向	Biotechnology & Applied Microbiology
语种	英语
出版者	NATURE PUBLISHING GROUP
WOS记录号	WOS:000450374000018
内容类型	期刊论文
源URL	[http://119.78.100.204/handle/2XEOYT63/4335]
专题	中国科学院计算技术研究所期刊论文_英文
通讯作者	Chi, Hao; He, Si-Min
作者单位	1.Sun Yat Sen Univ, Coll Ecol & Evolut, Guangdong Prov Key Lab Plant Resources, Guangzhou, Guangdong, Peoples R China 2.Sun Yat Sen Univ, Coll Ecol & Evolut, State Key Lab Biocontrol, Guangzhou, Guangdong, Peoples R China 3.Beijing Inst Life, Natl Ctr Prot Sci Beijing, Beijing Proteome Res Ctr, State Key Lab Prote, Beijing, Peoples R China 4.Natl Inst Biol Sci, Beijing, Peoples R China 5.Univ Chinese Acad Sci, Beijing, Peoples R China 6.Chinese Acad Sci, Key Lab Intelligent Informat Proc, Inst Comp Technol, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Niu, Xiu-Nan,Chi, Hao,Liu, Chao,et al. Comprehensive identification of peptides in tandem mass spectra using an efficient open search engine[J]. NATURE BIOTECHNOLOGY,2018,36(11):1059-+.
APA	Niu, Xiu-Nan.,Chi, Hao.,Liu, Chao.,Yang, Hao.,Zeng, Wen-Feng.,...&He, Si-Min.(2018).Comprehensive identification of peptides in tandem mass spectra using an efficient open search engine.NATURE BIOTECHNOLOGY,36(11),1059-+.
MLA	Niu, Xiu-Nan,et al."Comprehensive identification of peptides in tandem mass spectra using an efficient open search engine".NATURE BIOTECHNOLOGY 36.11(2018):1059-+.