Mutagenesis, Screening and industrialization of High Avermectin B1a Producing Strains from Streptomyces Avermitilis irradiated by C-12(6+) ion beam

doi:10.4028/www.scientific.net/AMR.339.652

	Mutagenesis, Screening and industrialization of High Avermectin B1a Producing Strains from Streptomyces Avermitilis irradiated by C-12(6+) ion beam
	Zhang, XD ; Ai, ZJ ; Liu, Jing ; Ma, Xiaoqi 2; Bo, Yongheng 1; Yarlagadda, P ; Wang, Shuyang1,2 ; Chen, Jihong2 ; Li, Wenjiang 2; Liang, Jianping 2
	2011
关键词	Irradiation Ion Beam of C-12(6+) streptomyces avermitilis Screening industrialization
卷号	339
DOI	10.4028/www.scientific.net/AMR.339.652
页码	652-+
英文摘要	Heavy ion irradiation induced mutation is a unique method of physical mutation, with various parameters, high LET and RBE characteristic. The spore suspension of streptomyces avermitilis were irradiated by carbon ions with doses of 0, 30, 40, 50, 60 and 70 Gy. The high avermectin producing strain was successfully obtained after the mutagenesis processing by heavy ion beam and the screening of orthomutation strains. Two strains(No.203 and No.148) which potency was 52004 mu g/ml was sieved and its potency increased 38.64% than the original strain. The obtained strains were used for 1 ton fermentation tank and the pilot 5-ton fermentation tank amplification tests.
会议录	ADVANCED MANUFACTURING SYSTEMS
会议录出版者	TRANS TECH PUBLICATIONS LTD
会议录出版地	KREUZSTRASSE 10, 8635 DURNTEN-ZURICH, SWITZERLAND
语种	英语
资助项目	Science and technology projects in Lanzhou[2009-2-13]
WOS研究方向	Engineering ; Materials Science
WOS记录号	WOS:000309383100126
内容类型	会议论文
源URL	[http://119.78.100.186/handle/113462/58501]
专题	近代物理研究所_生物物理研究室
通讯作者	Wang, Shuyang
作者单位	1.Gansu Agr Univ, Lanzhou 730070, Peoples R China 2.Chinese Acad Sci, Inst Modern Phys, Dept Biol Phys, Lanzhou 730000, Peoples R China
推荐引用方式 GB/T 7714	Zhang, XD,Ai, ZJ,Liu, Jing,et al. Mutagenesis, Screening and industrialization of High Avermectin B1a Producing Strains from Streptomyces Avermitilis irradiated by C-12(6+) ion beam[C]. 见:.