Ecto-5 '-nucleotidase expression is associated with the progression of renal cell carcinoma

doi:10.3892/ol.2015.3138

CORC > 近代物理研究所 > 中国科学院近代物理研究所 > 空间辐射生物研究室

	Ecto-5 '-nucleotidase expression is associated with the progression of renal cell carcinoma
	Song, Lei2,3 ; Wang, Wei 1; Yu, Yi 1; Zhou, Guangming2 ; Hu, Wentao 2; Dong, Chi 4; Pei, Hailong 2; Yue, Zhongjin 1
刊名	ONCOLOGY LETTERS
	2015-06-01
卷号	9 页码:2485-2494
关键词	renal cell carcinoma CD73 P-glycoprotein tumor progression prognosis
ISSN号	1792-1074
DOI	10.3892/ol.2015.3138
英文摘要	Renal cell carcinoma (RCC) is a common tissue tumor that occurs across all age groups and has become one of the types of cancer with the fastest increasing incidence. Due to the resistance of RCC chemo- and radiotherapy, surgery is the only currently effective treatment. Therefore, specific markers for the diagnosis and prognosis of RCC are expected to result in novel methods of treatment. Ecto-5'-nucleotidase, also termed cluster of differentiation (CD)73, is a protein that is activated in several types of aggressive cancer and may promote cancer progression. CD73 was examined in the present study to determine the association between the protein and RCC. The expression levels of CD73 in 159 RCC tissue sections and 30 paratumorous normal renal tissue samples obtained from 235 patients that underwent nephrectomy,were examined by immunohistochemical staining. By contrast, the expression level of P-glycoprotein (P-gp), a potential prognostic factor in RCC, was also examined in 85 RCC and 13 normal tissue samples. Intense CD73 expression was identified in 75 out of 159 RCC cell membranes compared with normal renal tissues. In contrast, there was high P-gp expression in the blood vessels of 42 out of 85 RCC tissues and there was no significant difference between the P-gp expression identified in RCC cells (34 out of 85) and the cell membrane of normal renal cells (2 out of 13). The expression level of CD73 in RCC cells was significantly associated with tumor type, tumor node metastasis (TNM) stage, and tumor grade. However, the expression of P-gp in RCC cells was only associated with the TNM stage and tumor grade. Using a multivariable Cox regression analysis, it was found that the median survival rate of RCC patients with intense CD73 expression in RCC cells was 62.06 +/- 5.35 months, which was drastically shorter compared with rare CD73 expression (103.72 +/- 3.67 months). In conclusion, the expression level of CD73 is significantly associated with RCC tumor progression and may serve as a favorable marker for the diagnosis and prognosis of RCC, in addition to being a therapeutic target for the treatment of RCC.
资助项目	National Science Foundation of China[30571860]
WOS关键词	BREAST-CANCER CELLS ; RESISTANCE GENE-PRODUCT ; MULTIDRUG-RESISTANCE ; P-GLYCOPROTEIN ; EXTRACELLULAR ADENOSINE ; MASS-SPECTROMETRY ; DRUG-RESISTANCE ; HUMAN-MELANOMA ; CD73 ; METASTASIS
WOS研究方向	Oncology
语种	英语
出版者	SPANDIDOS PUBL LTD
WOS记录号	WOS:000355497800010
资助机构	National Science Foundation of China
内容类型	期刊论文
源URL	[http://119.78.100.186/handle/113462/39870]
专题	近代物理研究所_空间辐射生物研究室
通讯作者	Yue, Zhongjin
作者单位	1.Second Hosp Lanzhou Univ, Key Lab Urinary Dis Gansu Prov, Dept Urol Surg, Lanzhou 730030, Gansu, Peoples R China 2.Chinese Acad Sci, Inst Modern Phys, Key Lab Heavy Ion Radiat Biol & Med, Dept Space Radiobiol, Lanzhou 730000, Gansu, Peoples R China 3.Northwest Univ Nat, Coll Med, Lanzhou 730030, Gansu, Peoples R China 4.Second Hosp Lanzhou Univ, Dept Pathol, Lanzhou 730000, Gansu, Peoples R China
推荐引用方式 GB/T 7714	Song, Lei,Wang, Wei,Yu, Yi,et al. Ecto-5 '-nucleotidase expression is associated with the progression of renal cell carcinoma[J]. ONCOLOGY LETTERS,2015,9:2485-2494.
APA	Song, Lei.,Wang, Wei.,Yu, Yi.,Zhou, Guangming.,Hu, Wentao.,...&Yue, Zhongjin.(2015).Ecto-5 '-nucleotidase expression is associated with the progression of renal cell carcinoma.ONCOLOGY LETTERS,9,2485-2494.
MLA	Song, Lei,et al."Ecto-5 '-nucleotidase expression is associated with the progression of renal cell carcinoma".ONCOLOGY LETTERS 9(2015):2485-2494.