Early effects of carbon-ion irradiation on murine lymphocytes and thymocytes | |
Xie, Yi1,3![]() ![]() | |
刊名 | ADVANCES IN SPACE RESEARCH
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2007 | |
卷号 | 40期号:4页码:563-567 |
关键词 | (12)c(6+) Heavy Ion Cell Cycle Apoptosis Immunocyte Outer Space Mouse |
ISSN号 | 0273-1177 |
DOI | 10.1016/j.asr.2007.04.092 |
英文摘要 | To estimate the biological risks from space radiation encountered by cosmonauts in outer space, the effects from whole-body exposure to carbon ions or X-rays irradiations at 0, 0.39, 0.55 and 1 Gy at a dose rate of 0.2 Gy/min were investigated in BALB/c mice. The relative thymus and spleen weights were measured at 24 h after exposure, and the cell cycle distribution and percentage of apoptosis of thymocytes and spleen and peripheral blood lymphocytes were determined by flow cytometry. The data showed that exposure to carbon ions delayed cell progression of peripheral blood lymphocytes in S-phase, and delayed thymocytes and spleen lymphocytes in G(0)/G(1)-phase. Apoptosis of thymocytes and peripheral blood lymphocytes induced by carbon ions increased more rapidly with dose than was the case for X-rays. There were some differences between the relative weight loss of the thymus and the spleen with increasing dose of either carbon ions or X-rays. The results obtained provide evidence of dose- and organ-specific differences induced by carbon ions compared to X-rays, with increased apoptosis in peripheral blood lymphocytes and thymocytes, but not spleen lymphocytes. Our data may suggest that further work would be of interest to estimate risk of changes in immune function during particle radiation exposures in space travel. (c) 2007 COSPAR. Published by Elsevier Ltd. All rights reserved. |
WOS关键词 | Radiation ; Cells ; Elimination ; Cytokines ; Exposure ; Spleen |
WOS研究方向 | Astronomy & Astrophysics ; Geology ; Meteorology & Atmospheric Sciences |
语种 | 英语 |
出版者 | ELSEVIER SCI LTD |
WOS记录号 | WOS:000253589500016 |
公开日期 | 2010-10-29 |
内容类型 | 期刊论文 |
源URL | [http://ir.imp.cas.cn/handle/113462/5805] ![]() |
专题 | 近代物理研究所_近代物理研究所知识存储(2010之前) |
作者单位 | 1.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 2.Inst Med Sci Gansu Province, Dept Toxicol, Lanzhou 730000, Peoples R China 3.Chinese Acad Sci, Inst Modern Phys, Dept Radiol, Lanzhou 730000, Gansu Province, Peoples R China |
推荐引用方式 GB/T 7714 | Xie, Yi,Zhang, Hong,Dang, Bingrong,et al. Early effects of carbon-ion irradiation on murine lymphocytes and thymocytes[J]. ADVANCES IN SPACE RESEARCH,2007,40(4):563-567. |
APA | Xie, Yi.,Zhang, Hong.,Dang, Bingrong.,Bing, Tao.,Hao, Jifang.,...&Wang, Xiaohu.(2007).Early effects of carbon-ion irradiation on murine lymphocytes and thymocytes.ADVANCES IN SPACE RESEARCH,40(4),563-567. |
MLA | Xie, Yi,et al."Early effects of carbon-ion irradiation on murine lymphocytes and thymocytes".ADVANCES IN SPACE RESEARCH 40.4(2007):563-567. |
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