A method on theoretical simulation of chromosome breaks in cells exposed to heavy ions

doi:10.2478/v10019-007-0036-3

CORC > 近代物理研究所 > 中国科学院近代物理研究所 > 近代物理研究所知识存储（2010之前）

	A method on theoretical simulation of chromosome breaks in cells exposed to heavy ions
	Yang, Jianshe 1,2,3; Li, Wenjian2 ; Jing, Xigang2 ; Wang, Zhuanzi2 ; Gao, Qingxiang 2
刊名	RADIOLOGY AND ONCOLOGY
	2008
卷号	42 期号:1 页码:32-38
关键词	theoretical simulation chromosome breaks cells heavy ions
ISSN号	1318-2099
DOI	10.2478/v10019-007-0036-3
英文摘要	Background. The aim of this study is to assess an easy and quick method on simulating chromosome breaks in cells exposed to heavy charged particles. Methods. The theoretical value of chromosome break was calculated, and the validated comparison with the experimental value by using a premature chromosome condensation technique was done. Results. A good consistence was found to be appeared between the theoretical and experimental value. Conclusions. This suggested that a higher relative biological effectiveness of heavy ions was closely correlated with its physical characteristics and besides, a safe approach on predicting chromosome breaks in cells exposed to heavy ions at off-line environment come to be considered. Furthermore, three key factors influencing the theoretical simulation was investigated and discussed.
WOS关键词	INTRINSIC RADIOSENSITIVITY ; HUMAN FIBROBLASTS ; CONDENSATION ; CARCINOMA ; RADIATION ; SURVIVAL ; ABERRATIONS ; INDUCTION ; CERVIX ; DAMAGE
WOS研究方向	Oncology ; Radiology, Nuclear Medicine & Medical Imaging
语种	英语
出版者	ASSOC RADIOLOGY & ONCOLOGY
WOS记录号	WOS:000257813000005
公开日期	2010-10-29
内容类型	期刊论文
源URL	[http://ir.imp.cas.cn/handle/113462/5681]
专题	近代物理研究所_近代物理研究所知识存储（2010之前）近代物理研究所_生物物理研究室
通讯作者	Yang, Jianshe
作者单位	1.Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai, Peoples R China 2.Chinese Acad Sci, Inst Modern Phys, Lanzhou, Peoples R China 3.NW Normal Univ, Sch Life Sci, Lanzhou, Peoples R China
推荐引用方式 GB/T 7714	Yang, Jianshe,Li, Wenjian,Jing, Xigang,et al. A method on theoretical simulation of chromosome breaks in cells exposed to heavy ions[J]. RADIOLOGY AND ONCOLOGY,2008,42(1):32-38.
APA	Yang, Jianshe,Li, Wenjian,Jing, Xigang,Wang, Zhuanzi,&Gao, Qingxiang.(2008).A method on theoretical simulation of chromosome breaks in cells exposed to heavy ions.RADIOLOGY AND ONCOLOGY,42(1),32-38.
MLA	Yang, Jianshe,et al."A method on theoretical simulation of chromosome breaks in cells exposed to heavy ions".RADIOLOGY AND ONCOLOGY 42.1(2008):32-38.