Micronuclei induction in human lymphocytes induced by carbon ions exposion along the penetrate depth of ions in water

doi:10.1016/j.nimb.2009.06.007

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	Micronuclei induction in human lymphocytes induced by carbon ions exposion along the penetrate depth of ions in water
	Wang, Z. Z.1; Li, W. J.1; Zhi, D. J.2; Qu, Y.1 ; Jing, X. G.1
刊名	NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS
	2009-08-01
卷号	267 期号:15 页码:2521-2524
关键词	Carbon ions Micronuclei Depth of ions in water
ISSN号	0168-583X
DOI	10.1016/j.nimb.2009.06.007
英文摘要	Here we used cytokinesis-block micronucleus assay to measure the biological response along the penetrate depth of ions in water in human lymphocytes exposed to 100 MeV/u incident carbon ions in vitro. Polyethylene shielding was used to change the penetration depth of ions in water. A quantitative biological response curve was generated for micronuclei induction. The results showed a marked increase with the penetrate depth of ions in water in the micronuclei formation, which was consistent with a linear-energy-transfer dependent increase in biological effectiveness. The dose-response relationship for MN information was different at different penetrate depth of ions in water, at the 6 and 11.2 mm penetrate depth of ions in water, the dose-response relationships for the micronucleus frequencies induced by carbon ions irradiation were linear; while it was power function at 17.1 mm penetrate depth. (C) 2009 Elsevier B.V. All rights reserved.
资助项目	Talent Training Program for Young Scientist (PhD) in West China of the Chinese Academy of Sciences ; Chinese Academy of Sciences for Postgraduate students ; National Nature Science Foundation of China[10875153]
WOS关键词	CHROMOSOME-ABERRATIONS ; RADIATION ; CELLS ; ASSAY ; IRRADIATION ; THERAPY ; REGION ; DAMAGE ; BEAMS ; BLOCK
WOS研究方向	Instruments & Instrumentation ; Nuclear Science & Technology ; Physics
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000268617300010
资助机构	Talent Training Program for Young Scientist (PhD) in West China of the Chinese Academy of Sciences ; Chinese Academy of Sciences for Postgraduate students ; National Nature Science Foundation of China
公开日期	2010-10-29
内容类型	期刊论文
源URL	[http://ir.imp.cas.cn/handle/113462/5245]
专题	近代物理研究所_近代物理研究所知识存储（2010之前）近代物理研究所_生物物理研究室
通讯作者	Wang, Z. Z.
作者单位	1.Chinese Acad Sci, Inst Modern Phys, Radiobiol Lab, Lanzhou 730000, Gansu, Peoples R China 2.Lanzhou Univ, Inst Pharmaceut, Lanzhou 730000, Gansu, Peoples R China
推荐引用方式 GB/T 7714	Wang, Z. Z.,Li, W. J.,Zhi, D. J.,et al. Micronuclei induction in human lymphocytes induced by carbon ions exposion along the penetrate depth of ions in water[J]. NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS,2009,267(15):2521-2524.
APA	Wang, Z. Z.,Li, W. J.,Zhi, D. J.,Qu, Y.,&Jing, X. G..(2009).Micronuclei induction in human lymphocytes induced by carbon ions exposion along the penetrate depth of ions in water.NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS,267(15),2521-2524.
MLA	Wang, Z. Z.,et al."Micronuclei induction in human lymphocytes induced by carbon ions exposion along the penetrate depth of ions in water".NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS 267.15(2009):2521-2524.