Transcriptional response of murine bone marrow cells to total-body carbon-ion irradiation

doi:10.1016/j.mrgentox.2019.01.014

	Transcriptional response of murine bone marrow cells to total-body carbon-ion irradiation
	Liu, Fang 1,3; Wang, Zhuanzi1 ; Li, Wenjian1 ; Wei, Yanting 2
刊名	MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
	2019-03-01
卷号	839 页码:49-58
关键词	RNA-seq Transcriptomics
ISSN号	1383-5718
DOI	10.1016/j.mrgentox.2019.01.014
通讯作者	Wang, Zhuanzi(wangzz@impcas.ac.cn)
英文摘要	The need to understand the health effects of heavy ion irradiation is motivated by the use of this modality in radiotherapy and by the potential for exposure during space missions. We have studied the effects of carbon-ion total-body irradiation on the hematopoietic system of the mouse and, in particular, the transcriptional response of bone marrow (BM) cells. Carbon-ion irradiation caused BM cell DNA damage, apoptosis, elevated ROS, and myelosuppression. Transcriptomic analysis showed that overall gene expression in irradiated BM cells differed significantly from the controls. Of 253 genes that were modulated, 192 were up-regulated and 61 down-regulated. Gene ontology analysis showed that the modulated genes are involved in DNA damage response signaling, DNA repair, apoptosis, and the immune response. Kyoto Encyclopedia of Genes and Genomes pathway analysis indicated that these functions are regulated by the p38 MAPK, TNF, and apoptosis pathways. These findings indicate pathways that may be involved in protection against carbon ion radiation injury.
资助项目	National Natural Science Foundation of China ; NSFC[11575259]
WOS关键词	DNA-DAMAGE ; RADIATION ; EXPOSURE ; GENE ; EXPRESSION ; PROGENITOR ; LEUKEMIA ; REPAIR ; DEATH
WOS研究方向	Biotechnology & Applied Microbiology ; Genetics & Heredity ; Toxicology
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000459842200007
资助机构	National Natural Science Foundation of China ; NSFC
内容类型	期刊论文
源URL	[http://119.78.100.186/handle/113462/134633]
专题	中国科学院近代物理研究所
通讯作者	Wang, Zhuanzi
作者单位	1.Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Gansu, Peoples R China 2.Lanzhou Univ Technol, Sch Life Sci & Engn, Lanzhou 730000, Gansu, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Liu, Fang,Wang, Zhuanzi,Li, Wenjian,et al. Transcriptional response of murine bone marrow cells to total-body carbon-ion irradiation[J]. MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS,2019,839:49-58.
APA	Liu, Fang,Wang, Zhuanzi,Li, Wenjian,&Wei, Yanting.(2019).Transcriptional response of murine bone marrow cells to total-body carbon-ion irradiation.MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS,839,49-58.
MLA	Liu, Fang,et al."Transcriptional response of murine bone marrow cells to total-body carbon-ion irradiation".MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS 839(2019):49-58.