Function, clinical application, and strategies of Pre-mRNA splicing in cancer

doi:10.1038/s41418-018-0231-3

	Function, clinical application, and strategies of Pre-mRNA splicing in cancer
	Di, Cuixia1,2,3 ; Syafrizayanti 4,5; Zhang, Qianjing 1,2,3; Chen, Yuhong 1,2,3; Wang, Yupei 1,2,3; Zhang, Xuetian 1,2,3; Liu, Yang1,2 ; Sun, Chao 1,2; Zhang, Hong1,2 ; Hoheisel, Jorg D.4
刊名	CELL DEATH AND DIFFERENTIATION
	2019-07-01
卷号	26 页码:1181-1194
ISSN号	1350-9047
DOI	10.1038/s41418-018-0231-3
英文摘要	Pre-mRNA splicing is a fundamental process that plays a considerable role in generating protein diversity. Pre-mRNA splicing is also the key to the pathology of numerous diseases, especially cancers. In this review, we discuss how aberrant splicing isoforms precisely regulate three basic functional aspects in cancer: proliferation, metastasis and apoptosis. Importantly, clinical function of aberrant splicing isoforms is also discussed, in particular concerning drug resistance and radiosensitivity. Furthermore, this review discusses emerging strategies how to modulate pathologic aberrant splicing isoforms, which are attractive, novel therapeutic agents in cancer. Last we outline current and future directions of isoforms diagnostic methodologies reported so far in cancer. Thus, it is highlighting significance of aberrant splicing isoforms as markers for cancer and as targets for cancer therapy.
资助项目	national Key R&D project of the Chinese Ministry of Science and Technology[2016YFC0904600] ; Key Program of the National Natural Science Foundation of China[U1432248] ; Key Program of the National Natural Science Foundation of China[U1632270] ; National Natural Science Foundation of China[11675234] ; National Natural Science Foundation of China[11575262] ; Affinomics consortium - European Union[Health-F4-2010-241481] ; Natural Science Foundation of Gansu[17JR5RA310]
WOS关键词	IN-VITRO ; BCL-X ; ANTISENSE OLIGONUCLEOTIDES ; IONIZING-RADIATION ; CELL-DEATH ; EXPRESSION ; RESISTANCE ; THERAPY ; APOPTOSIS ; ISOFORMS
WOS研究方向	Biochemistry & Molecular Biology ; Cell Biology
语种	英语
出版者	NATURE PUBLISHING GROUP
WOS记录号	WOS:000470970300001
资助机构	national Key R&D project of the Chinese Ministry of Science and Technology ; Key Program of the National Natural Science Foundation of China ; National Natural Science Foundation of China ; Affinomics consortium - European Union ; Natural Science Foundation of Gansu
内容类型	期刊论文
源URL	[http://119.78.100.186/handle/113462/87712]
专题	中国科学院近代物理研究所
通讯作者	Zhang, Hong; Hoheisel, Jorg D.
作者单位	1.Chinese Acad Sci, Inst Modern Phys, Dept Radiat Med, Lanzhou 730000, Gansu, Peoples R China 2.Chinese Acad Sci, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou 730000, Gansu, Peoples R China 3.Univ Chinese Acad Sci, Coll Life Sci, Beijing, Peoples R China 4.German Canc Res Ctr, Div Funct Genome Anal, Neuenheimer Feld 580, D-69120 Heidelberg, Germany 5.Andalas Univ, Fac Math & Nat Sci, Dept Chem, Kampus Limau Manis, Padang, Indonesia
推荐引用方式 GB/T 7714	Di, Cuixia,Syafrizayanti,Zhang, Qianjing,et al. Function, clinical application, and strategies of Pre-mRNA splicing in cancer[J]. CELL DEATH AND DIFFERENTIATION,2019,26:1181-1194.
APA	Di, Cuixia.,Syafrizayanti.,Zhang, Qianjing.,Chen, Yuhong.,Wang, Yupei.,...&Hoheisel, Jorg D..(2019).Function, clinical application, and strategies of Pre-mRNA splicing in cancer.CELL DEATH AND DIFFERENTIATION,26,1181-1194.
MLA	Di, Cuixia,et al."Function, clinical application, and strategies of Pre-mRNA splicing in cancer".CELL DEATH AND DIFFERENTIATION 26(2019):1181-1194.