Delay Hill dynamics in regulatory biological systems

doi:10.1039/c0mb00133c

	Delay Hill dynamics in regulatory biological systems
	Liu, Bo 1; Yan, Shiwei 1,2,3; Wang, Qi 1
刊名	MOLECULAR BIOSYSTEMS
	2011
卷号	7 页码:457-463
ISSN号	1742-206X
DOI	10.1039/c0mb00133c
英文摘要	We explore one of the best-studied protein circuits in human cells, the negative feedback loop between the tumor suppressor p53 and the oncogene Mdm2 following nuclear irradiation. Using stochastic delay differential equations and the Gillespie algorithm, we illustrate the distinct oscillatory dynamics at the single-cell and population-cell levels which were found in the recent experiments. The oscillatory dynamics of p53-Mdm2 interaction appears as coherent resonance with delay and noise in individual cells. Dephasing mechanisms provide the origin of damped oscillation at the population level out of the sustained one at the single-cell level. The non-Gaussian nature of distributions of protein populations results from the interplay between time delay and nonlinearity of reaction processes. Our findings may lead to new insights related to the effects of noise and cancer therapy.
资助项目	Scientific Research Foundation for the Returned Overseas Chinese Scholars, Ministry of Personnel of China[MOP2006138]
WOS关键词	P53-MDM2 FEEDBACK LOOP ; OSCILLATORY ACTIVITIES ; TIME-DELAY ; P53 ; NETWORKS ; CELLS ; MODEL ; SIMULATION ; EXPRESSION
WOS研究方向	Biochemistry & Molecular Biology
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000286390600019
内容类型	期刊论文
源URL	[http://119.78.100.186/handle/113462/56995]
专题	中国科学院近代物理研究所
通讯作者	Yan, Shiwei
作者单位	1.Beijing Normal Univ, Coll Nucl Sci & Technol, Beijing 100875, Peoples R China 2.Beijing Radiat Ctr, Beijing 100875, Peoples R China 3.Natl Lab Heavy Ion Accelerator Lanzhou, Ctr Theoret Phys, Lanzhou 730000, Peoples R China
推荐引用方式 GB/T 7714	Liu, Bo,Yan, Shiwei,Wang, Qi. Delay Hill dynamics in regulatory biological systems[J]. MOLECULAR BIOSYSTEMS,2011,7:457-463.
APA	Liu, Bo,Yan, Shiwei,&Wang, Qi.(2011).Delay Hill dynamics in regulatory biological systems.MOLECULAR BIOSYSTEMS,7,457-463.
MLA	Liu, Bo,et al."Delay Hill dynamics in regulatory biological systems".MOLECULAR BIOSYSTEMS 7(2011):457-463.