Effects of shielding on the induction of 53BP1 foci and micronuclei after Fe ion exposures

doi:10.1093/jrr/rrt078

	Effects of shielding on the induction of 53BP1 foci and micronuclei after Fe ion exposures
	Hu, Wentao 1,2; Pei, Hailong 1,2; Li, He 1,2; Ding, Nan 1,2; He, Jinpeng 1,2; Wang, Jufang 1; Furusawa, Yoshiya 3; Hirayama, Ryoichi 3; Matsumoto, Yoshitaka 3; Liu, Cuihua 3
刊名	JOURNAL OF RADIATION RESEARCH
	2014
卷号	55 页码:10-16
关键词	Space Radiation Shielding Secondary Particles Survival Dna Damage
ISSN号	0449-3060
DOI	10.1093/jrr/rrt078
文献子类	Article
英文摘要	High atomic number and high-energy (HZE) particles in deep space are of low abundance but substantially contribute to the biological effects of space radiation. Shielding is so far the most effective way to partially protect astronauts from these highly penetrating particles. However, simulated calculations and measurements have predicted that secondary particles resulting from the shielding of cosmic rays produce a significant fraction of the total dose and dose equivalent. In this study, we investigated the biological effects of secondary radiation with two cell types, and with cells exposed in different phases of the cell cycle, by comparing the biological effects of a 200 MeV/u iron beam with a shielded beam in which the energy of the iron ion beam was decreased from 500 MeV/u to 200 MeV/u with PMMA, polyethylene (PE), or aluminum. We found that beam shielding resulted in increased induction of 53BP1 foci and micronuclei in a cell-type-dependent manner compared with the unshielded 200 MeV/u Fe ion beam. These findings provide experimental proof that the biological effects of secondary particles resulting from the interaction between HZE particles and shielding materials should be considered in shielding design.
资助项目	National Natural Science Foundations of China[10979062] ; National Natural Science Foundations of China[U1232125] ; National Natural Science Foundations of China[31270895]
WOS关键词	SPACE RADIATION PROTECTION ; GALACTIC COSMIC-RAYS ; IONIZING-RADIATION ; HUMAN-CELLS ; DNA-DAMAGE ; HEAVY-IONS ; RISK ; EXPLORATION ; PARTICLES ; LESIONS
WOS研究方向	Life Sciences & Biomedicine - Other Topics ; Radiology, Nuclear Medicine & Medical Imaging
语种	英语
出版者	OXFORD UNIV PRESS
WOS记录号	WOS:000329861800003
内容类型	期刊论文
源URL	[http://119.78.100.186/handle/113462/49771]
专题	中国科学院近代物理研究所
通讯作者	Zhou, Guangming
作者单位	1.Chinese Acad Sci, Key Lab Heavy Ion Radiat Biol & Med, Inst Modern Phys, Dept Space Radiobiol, Lanzhou 730000, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Natl Inst Radiol Sci, Res Ctr Charged Particle Therapy, Chiba 263555, Japan 4.Astronaut Ctr China, State Key Lab Space Med Fundamentat & Applicat, Beijing 100094, Peoples R China 5.Keio Univ, Sch Med, Dept Radiol, Tokyo 1608582, Japan
推荐引用方式 GB/T 7714	Hu, Wentao,Pei, Hailong,Li, He,et al. Effects of shielding on the induction of 53BP1 foci and micronuclei after Fe ion exposures[J]. JOURNAL OF RADIATION RESEARCH,2014,55:10-16.
APA	Hu, Wentao.,Pei, Hailong.,Li, He.,Ding, Nan.,He, Jinpeng.,...&Zhou, Guangming.(2014).Effects of shielding on the induction of 53BP1 foci and micronuclei after Fe ion exposures.JOURNAL OF RADIATION RESEARCH,55,10-16.
MLA	Hu, Wentao,et al."Effects of shielding on the induction of 53BP1 foci and micronuclei after Fe ion exposures".JOURNAL OF RADIATION RESEARCH 55(2014):10-16.