Licochalcone B inhibits growth of bladder cancer cells by arresting cell cycle progression and inducing apoptosis

doi:10.1016/j.fct.2013.12.030

	Licochalcone B inhibits growth of bladder cancer cells by arresting cell cycle progression and inducing apoptosis
	Yuan, Xuan 1; Li, Tao 1; Xiao, Erlong 1; Zhao, Hong 2; Li, Yongqian 1; Fu, Shengjun 1; Gan, Lu4 ; Wang, Zhenhua 3; Zheng, Qiusheng 2,3; Wang, Zhiping 1
刊名	FOOD AND CHEMICAL TOXICOLOGY
	2014-03-01
卷号	65 页码:242-251
关键词	Licochalcone b Bladder Cancer s Phase Arrest Apoptosis
ISSN号	0278-6915
DOI	10.1016/j.fct.2013.12.030
文献子类	Article
英文摘要	To examine the mechanisms by which licochalcone B (LCB) inhibits the proliferation of human malignant bladder cancer cell lines (T24 and EJ) in vitro and antitumor activity in vivo in M849 (murine bladder cancer cell line) tumor model. Exposure of T24 or EJ cells to LCB significantly inhibited cell lines proliferation in a concentration-dependent and time-dependent manner, and resulted in S phase arrest in T24 or EJ cells, respectively. LCB treatment decreased the expression of cyclin A, cyclin-dependent kinase (CDK1 and CDK2) mRNA, cell division cycle 25 (Cdc25A and Cdc25B) protein. In addition, LCB treatment down-regulated Bcl-2 and survivin expression, enhanced Bax expression, activated caspase-3 and cleaved poly (ADP-ribose) polymerase (PARP) protein. Consistently, the tumorigenicity of LCB-treated MB49 cells was limited significantly by using the colony formation assay in vitro and the MB49 tumor model performed in C57BL/6 mice in vivo. These findings provide support for the use of LCB in chemoprevention and bladder cancer therapy. (C) 2013 Elsevier Ltd. All rights reserved.
资助项目	International Cooperation Projects[2012BC001]
WOS关键词	CHALCONE FLAVOKAWAIN ; ROS GENERATION ; KAVA CHALCONE ; TUMOR-GROWTH ; IN-VITRO ; PROTEIN ; THERAPY ; PATHWAY ; CDC25B ; PHASE
WOS研究方向	Food Science & Technology ; Toxicology
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000332500500031
内容类型	期刊论文
源URL	[http://119.78.100.186/handle/113462/49335]
专题	中国科学院近代物理研究所
通讯作者	Zheng, Qiusheng
作者单位	1.Lanzhou Univ, Inst Urol, Hosp 2, Lanzhou 730030, Peoples R China 2.Shihezi Univ, Key Lab Xinjiang Endem Phytomed Resources, Minist Educ, Sch Pharm, Shihezi 832002, Peoples R China 3.Yantai Univ, Sch Life Sci, Yantai 264000, Peoples R China 4.Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Peoples R China
推荐引用方式 GB/T 7714	Yuan, Xuan,Li, Tao,Xiao, Erlong,et al. Licochalcone B inhibits growth of bladder cancer cells by arresting cell cycle progression and inducing apoptosis[J]. FOOD AND CHEMICAL TOXICOLOGY,2014,65:242-251.
APA	Yuan, Xuan.,Li, Tao.,Xiao, Erlong.,Zhao, Hong.,Li, Yongqian.,...&Wang, Zhiping.(2014).Licochalcone B inhibits growth of bladder cancer cells by arresting cell cycle progression and inducing apoptosis.FOOD AND CHEMICAL TOXICOLOGY,65,242-251.
MLA	Yuan, Xuan,et al."Licochalcone B inhibits growth of bladder cancer cells by arresting cell cycle progression and inducing apoptosis".FOOD AND CHEMICAL TOXICOLOGY 65(2014):242-251.