Protective Effects of Shikonin on Brain Injury Induced by Carbon Ion Beam Irradiation in Mice

doi:10.3967/bes2015.019

	Protective Effects of Shikonin on Brain Injury Induced by Carbon Ion Beam Irradiation in Mice
	Gan Lu1,2,3 ; Wang Zhen Hua 4; Zhang Hong1,2,3 ; Zhou Rong 1,2,3; Sun Chao 1,2,3; Liu Yang1,2,3 ; Si Jing1,2,3 ; Liu Yuan Yuan 1,2,3; Wang Zhen Guo 5
刊名	BIOMEDICAL AND ENVIRONMENTAL SCIENCES
	2015-02-01
卷号	28 页码:148-151
ISSN号	0895-3988
DOI	10.3967/bes2015.019
文献子类	Letter
英文摘要	Radiation encephalopathy is the main complication of cranial radiotherapy. It can cause necrosis of brain tissue and cognitive dysfunction. Our previous work had proved that a natural antioxidant shikonin possessed protective effect on cerebral ischemic injury. Here we investigated the effects of shikonin on carbon ion beam induced radiation brain injury in mice. Pretreatment with shikonin significantly increased the SOD and CAT activities and the ratio of GSH/GSSG in mouse brain tissues compared with irradiated group (P<0.01), while obviously reduced the MDA and PCO contents and the ROS levels derived from of the brain mitochondria. The shikonin also noticeably improved the spatial memory deficits caused by carbon ion beam irradiation. All results demonstrated that shikonin could improve the irradiated brain injury which might resulted from its modulation effects on the oxidative stress induced by the C-12(6+) ion beam.
WOS关键词	MOUSE-BRAIN ; DAMAGE ; RADIATION ; APOPTOSIS
WOS研究方向	Environmental Sciences & Ecology ; Public, Environmental & Occupational Health
语种	英语
出版者	CHINESE CENTER DISEASE CONTROL & PREVENTION
WOS记录号	WOS:000353296600009
内容类型	期刊论文
源URL	[http://119.78.100.186/handle/113462/47979]
专题	中国科学院近代物理研究所
通讯作者	Zhang Hong
作者单位	1.Chinese Acad Sci, Inst Modern Phys, Dept Heavy Ion Irradiat Med, Lanzhou 730000, Gansu, Peoples R China 2.Chinese Acad Sci, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou 730000, Gansu, Peoples R China 3.Key Lab Heavy Ion Radiat Med Gansu Prov, Lanzhou 730000, Gansu, Peoples R China 4.Yantai Univ, Sch Life Sci, Yantai 264000, Shandong, Peoples R China 5.Lanzhou Univ, Sch Hosp Stomatol, Lanzhou 730000, Gansu, Peoples R China
推荐引用方式 GB/T 7714	Gan Lu,Wang Zhen Hua,Zhang Hong,et al. Protective Effects of Shikonin on Brain Injury Induced by Carbon Ion Beam Irradiation in Mice[J]. BIOMEDICAL AND ENVIRONMENTAL SCIENCES,2015,28:148-151.
APA	Gan Lu.,Wang Zhen Hua.,Zhang Hong.,Zhou Rong.,Sun Chao.,...&Wang Zhen Guo.(2015).Protective Effects of Shikonin on Brain Injury Induced by Carbon Ion Beam Irradiation in Mice.BIOMEDICAL AND ENVIRONMENTAL SCIENCES,28,148-151.
MLA	Gan Lu,et al."Protective Effects of Shikonin on Brain Injury Induced by Carbon Ion Beam Irradiation in Mice".BIOMEDICAL AND ENVIRONMENTAL SCIENCES 28(2015):148-151.