Epigenetic actions of environmental factors and promising drugs for cancer therapy (Review)

doi:10.3892/ol.2017.7597

	Epigenetic actions of environmental factors and promising drugs for cancer therapy (Review)
	Bai, Zhong-Tian 1,2; Bai, Bing 1,2; Zhu, Jun 3; Di, Cui-Xa 4; Li, Xun 1,2; Zhou, Wen-Ce 1,2
刊名	ONCOLOGY LETTERS
	2018-02-01
卷号	15 页码:2049-2056
关键词	epigenetic modification environmental factor promising drug cancer therapy
ISSN号	1792-1074
DOI	10.3892/ol.2017.7597
英文摘要	Carcinogenesis is known to be primarily associated with gene mutations. Recently, increasing evidence has suggested that epigenetic events also serve crucial roles in tumor etiology. Environmental factors, including nutrition, toxicants and ethanol, are involved in carcinogenesis through inducing epigenetic modifications, such as DNA methylation, histone deacetylase and miRNA regulation. Studying epigenetic mechanisms has facilitated the development of early diagnostic strategies and potential therapeutic avenues. Modulation at the epigenetic level, including reversing epigenetic modifications using targeted drugs, has demonstrated promise in cancer therapy. Therefore, identifying novel epigenetic biomarkers and therapeutic targets has potential for the future of cancer therapy. The present review discusses the environmental factors involved in epigenetic modifications and potential drug candidates for cancer therapy.
资助项目	National Natural Science Fund of China[31570509] ; National Natural Science Fund of China[81702326] ; Gansu Province Science Foundation for Distinguished Young Scholars[1606RJDA317] ; Science and Technology Program of Lanzhou City[2015-3-93]
WOS关键词	HISTONE DEACETYLASE INHIBITOR ; CELL LUNG-CANCER ; VIRUS X PROTEIN ; COLORECTAL-CANCER ; VALPROIC ACID ; TRANSGENERATIONAL INHERITANCE ; HEPATOCELLULAR-CARCINOMA ; ANTITUMOR-ACTIVITY ; SOLID TUMORS ; DISEASE
WOS研究方向	Oncology
语种	英语
出版者	SPANDIDOS PUBL LTD
WOS记录号	WOS:000426145100002
资助机构	National Natural Science Fund of China ; Gansu Province Science Foundation for Distinguished Young Scholars ; Science and Technology Program of Lanzhou City
内容类型	期刊论文
源URL	[http://119.78.100.186/handle/113462/47383]
专题	中国科学院近代物理研究所
通讯作者	Zhou, Wen-Ce
作者单位	1.Lanzhou Univ, Hosp 1, Key Lab Biotherapy & Regenerat Med, Dept Gen Surg 2, 1 Donggang West St, Lanzhou 730000, Gansu, Peoples R China 2.Lanzhou Univ, Med Coll Canc Ctr, Hepatopancreatobiliary Surg Inst Gansu, Lanzhou 730000, Gansu, Peoples R China 3.Lanzhou Univ, Hosp 1, Pathol Dept, Donggang Branch Courts, Lanzhou 730000, Gansu, Peoples R China 4.Chinese Acad Sci, Inst Modern Phys, Dept Heavy Ion Radiat Med, Lanzhou 730000, Gansu, Peoples R China
推荐引用方式 GB/T 7714	Bai, Zhong-Tian,Bai, Bing,Zhu, Jun,et al. Epigenetic actions of environmental factors and promising drugs for cancer therapy (Review)[J]. ONCOLOGY LETTERS,2018,15:2049-2056.
APA	Bai, Zhong-Tian,Bai, Bing,Zhu, Jun,Di, Cui-Xa,Li, Xun,&Zhou, Wen-Ce.(2018).Epigenetic actions of environmental factors and promising drugs for cancer therapy (Review).ONCOLOGY LETTERS,15,2049-2056.
MLA	Bai, Zhong-Tian,et al."Epigenetic actions of environmental factors and promising drugs for cancer therapy (Review)".ONCOLOGY LETTERS 15(2018):2049-2056.