Protective effect of mitochondrial-targeted antioxidant MitoQ against iron ion Fe-56 radiation induced brain injury in mice

doi:10.1016/j.taap.2018.01.003

	Protective effect of mitochondrial-targeted antioxidant MitoQ against iron ion Fe-56 radiation induced brain injury in mice
	Gan, Lu1,2,3 ; Wang, Zhenhua 5; Si, Jing 1,2; Zhou, Rong 1,2; Sun, Chao 1,2; Liu, Yang 1,2; Ye, Yancheng 4; Zhang, Yanshan 4; Liu, Zhiyuan 6; Zhang, Hong 1,2,4
刊名	TOXICOLOGY AND APPLIED PHARMACOLOGY
	2018-02-15
卷号	341 页码:1-7
关键词	Fe-56 ion radiation Oxidative stress Mitochondria MitoQ
ISSN号	0041-008X
DOI	10.1016/j.taap.2018.01.003
英文摘要	Exposure to iron ion Fe-56 radiation OR) during space missions poses a significant risk to the central nervous system and radiation exposure is intimately linked to the production of reactive oxygen species (ROS). MitoQ is a mitochondria-targeted antioxidant that has been shown to decrease oxidative damage and lower mitochondria] ROS in a number of animal models. Therefore, the present study aimed to investigate role of the mitochondrial targeted antioxidant MitoQ against Fe-56 particle irradiation-induced oxidative damage and mitochondria dysfunction in the mouse brains. Increased ROS levels were observed in mouse brains after IR compared with the control group. Enhanced ROS production leads to disruption of cellular antioxidant defense systems, mitochondrial respiration dysfunction, altered mitochondria dynamics and increased release of cytochrome c (cyto c) from mitochondria into cytosol resulting in apoptotic cell death. MitoQ reduced IR-induced oxidative stress (decreased ROS production and increased SOD, CAT activities) with decreased lipid peroxidation as well as reduced protein and DNA oxidation. MitoQ also protected mitochondria] respiration after IR. In addition, MitoQ increased the expression of mitofusin2 (Mfn2) and optic atrophy genel (OPAL), and decreased the expression of dynamic-like protein (Drpl). MitoQ also suppressed mitochondrial DNA damage, cyto c release, and caspase-3 activity in IR-treated mice compared to the control group. These results demonstrate that MitoQ may protect against IR-induced brain injury.
资助项目	National Key Projects of Research and Development[2016YFC0904600] ; Key Program of National Natural Science Foundation of China[U1432248] ; National Natural Science Foundation of China[11775280] ; National Natural Science Foundation of China[11575262] ; Fundamental Research Funds for the Central Universities[31920160048]
WOS关键词	INDUCED OXIDATIVE STRESS ; SPACE RADIATION ; EMBRYONIC-DEVELOPMENT ; FISSION ; DAMAGE ; FUSION ; DYNAMICS ; MOUSE ; DNA ; DYSFUNCTION
WOS研究方向	Pharmacology & Pharmacy ; Toxicology
语种	英语
出版者	ACADEMIC PRESS INC ELSEVIER SCIENCE
WOS记录号	WOS:000425706900001
资助机构	National Key Projects of Research and Development ; Key Program of National Natural Science Foundation of China ; National Natural Science Foundation of China ; Fundamental Research Funds for the Central Universities
内容类型	期刊论文
源URL	[http://119.78.100.186/handle/113462/47362]
专题	中国科学院近代物理研究所
通讯作者	Wang, Zhenhua; Zhang, Hong
作者单位	1.Chinese Acad Sci, Inst Modern Phys, Dept Radiat Med, Lanzhou 730000, Gansu, Peoples R China 2.Chinese Acad Sci, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou 730000, Gansu, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100039, Peoples R China 4.Gansu Wuwei Tumor Hosp, Dept Sci & Technol, Wuwei 733000, Gansu, Peoples R China 5.Yantai Univ, Ctr Mitochondria & Hlth Aging, Sch Life Sci, Yantai 264000, Peoples R China 6.Northwest Univ Nationalities, Coll Chem Engn, Gansu Key Lab Environm Friendly Composites & Biom, Lanzhou 730030, Gansu, Peoples R China
推荐引用方式 GB/T 7714	Gan, Lu,Wang, Zhenhua,Si, Jing,et al. Protective effect of mitochondrial-targeted antioxidant MitoQ against iron ion Fe-56 radiation induced brain injury in mice[J]. TOXICOLOGY AND APPLIED PHARMACOLOGY,2018,341:1-7.
APA	Gan, Lu.,Wang, Zhenhua.,Si, Jing.,Zhou, Rong.,Sun, Chao.,...&Zhang, Hong.(2018).Protective effect of mitochondrial-targeted antioxidant MitoQ against iron ion Fe-56 radiation induced brain injury in mice.TOXICOLOGY AND APPLIED PHARMACOLOGY,341,1-7.
MLA	Gan, Lu,et al."Protective effect of mitochondrial-targeted antioxidant MitoQ against iron ion Fe-56 radiation induced brain injury in mice".TOXICOLOGY AND APPLIED PHARMACOLOGY 341(2018):1-7.