Stainless Steel Hollow Microspheres for Arterial Embolization Hyperthermia

doi:10.1007/s40846-017-0252-2

	Stainless Steel Hollow Microspheres for Arterial Embolization Hyperthermia
	Wu, Jianan 1; Wang, Heng 1; Zhang, Han 1; Wei, Lanbin 1; Wang, Xiaowen 1; Wang, Xufei 2; Tang, Jintian 1
刊名	JOURNAL OF MEDICAL AND BIOLOGICAL ENGINEERING
	2017-12-01
卷号	37 页码:810-819
关键词	Stainless steel (SS) Microscaled Hollow Microsphere Magnetically induced hyperthermia (MIH) Arterial embolization hyperthermia (AEH)
ISSN号	1609-0985
DOI	10.1007/s40846-017-0252-2
英文摘要	To find a novel microscaled mediator suitable for arterial embolization hyperthermia (AEH). Stainless steel microspheres including both hollow (H1) and solid ones (S1) were produced with dispersing molten steel stream by water jet. Theoretically analyzing the power absorption of them in alternating magnetic field revealed that larger size and smaller permeability led to more heat generation. Higher field intensity and frequency also improved the heating power. Given the same condition, heating power per unit mass was greater in hollow microsphere than solid one. Microscopic observations of H1 and S1 were conducted along with particle size distribution, magnetization curve and heating power measurement. In vivo heating test, in vitro hyperthermia test and in vitro biocompatibility test were conducted for the finally selected mediator H1. The measured heating power of H1 and S1 met the theoretical values in low intensity field, but was considerably below expectation in strong field. Power density of H1 was clearly greater than that of S1 as theoretically predicted. The temperature of a rabbit ear in magnetic field injected with H1 maintained 50 A degrees C for 10 min. In vitro hyperthermia test showed its outstanding treatment effectiveness for cancer cells. Cytotoxicity of H1 was categorized as Grade I, which is regarded as no cytotoxicity. Stainless steel hollow microsphere H1 was a promising mediator for AEH for its high efficiency in heating tumor region and killing cancer cells as well as good biocompatibility.
资助项目	National Science and Technology Support Program of China[2012BAI15B04] ; National Natural Science Foundation[81470308]
WOS关键词	NANOPARTICLES
WOS研究方向	Engineering
语种	英语
出版者	SPRINGER HEIDELBERG
WOS记录号	WOS:000416836200003
资助机构	National Science and Technology Support Program of China ; National Natural Science Foundation
内容类型	期刊论文
源URL	[http://119.78.100.186/handle/113462/47043]
专题	中国科学院近代物理研究所
通讯作者	Tang, Jintian
作者单位	1.Tsinghua Univ, Dept Engn Phys, Key Lab Particle & Radiat Imaging, Minist Educ, Beijing 100084, Peoples R China 2.Fudan Univ, Inst Modern Phys, Shanghai 200433, Peoples R China
推荐引用方式 GB/T 7714	Wu, Jianan,Wang, Heng,Zhang, Han,et al. Stainless Steel Hollow Microspheres for Arterial Embolization Hyperthermia[J]. JOURNAL OF MEDICAL AND BIOLOGICAL ENGINEERING,2017,37:810-819.
APA	Wu, Jianan.,Wang, Heng.,Zhang, Han.,Wei, Lanbin.,Wang, Xiaowen.,...&Tang, Jintian.(2017).Stainless Steel Hollow Microspheres for Arterial Embolization Hyperthermia.JOURNAL OF MEDICAL AND BIOLOGICAL ENGINEERING,37,810-819.
MLA	Wu, Jianan,et al."Stainless Steel Hollow Microspheres for Arterial Embolization Hyperthermia".JOURNAL OF MEDICAL AND BIOLOGICAL ENGINEERING 37(2017):810-819.