Spot-scanning beam delivery with laterally-and longitudinally-mixed spot size pencil beams in heavy ion radiotherapy

doi:10.1088/1674-1137/41/9/098201

	Spot-scanning beam delivery with laterally-and longitudinally-mixed spot size pencil beams in heavy ion radiotherapy
	Yan, Yuan-Lin 1,2,3,4; Liu, Xin-Guo1,2,3 ; Dai, Zhong-Ying1,2,3 ; Ma, Yuan-Yuan1,2,3,4 ; He, Peng-Bo 1,2,3; Shen, Guo-Sheng1,2,3,4 ; Ji, Teng-Fei 1,2,3,4; Zhang, Hui 1,2,3,4; Li, Qiang1,2,3
刊名	CHINESE PHYSICS C
	2017-09-01
卷号	41 页码:10
关键词	heavy ion radiotherapy spot-scanning beam spot size mini spread-out Bragg peak (mini-SOBP) mini ridge filter (mini-RF)
ISSN号	1674-1137
DOI	10.1088/1674-1137/41/9/098201
英文摘要	The three-dimensional (3D) spot-scanning method is one of the most commonly used irradiation methods in charged particle beam radiotherapy. Generally, spot-scanning beam delivery utilizes the same size pencil beam to irradiate the tumor targets. Here we propose a spot-scanning beam delivery method with laterally- and longitudinally mixed size pencil beams for heavy ion radiotherapy. This uses pencil beams with a bigger spot size in the lateral direction and wider mini spread-out Bragg peak (mini-SOBP) to irradiate the inner part of a target volume, and pencil beams with a smaller spot size in the lateral direction and narrower mini-SOBP to irradiate the peripheral part of the target volume. Instead of being controlled by the accelerator, the lateral size of the pencil beam was adjusted by inserting Ta scatterers in the beam delivery line. The longitudinal size of the pencil beam (i.e. the width of the mini-SOBP) was adjusted by tilting mini ridge filters along the beam direction. The new spot-scanning beam delivery using carbon ions was investigated theoretically and compared with traditional spot-scanning beam delivery. Our results show that the new spot-scanning beam delivery has smaller lateral penumbra, steeper distal dose fall-off and the dose homogeneity (1-standard deviation/mean) in the target volume is better than 95%.
资助项目	Key Project of National Natural Science Foundation of China[U1232207] ; National Key Technology Support Program of the Ministry of Science and Technology of China[2015BAI01B11] ; National Key Research and Development Program of the Ministry of Science and Technology of China[2016YFC0904602] ; National Natural Science Foundation of China[11075191] ; National Natural Science Foundation of China[11205217] ; National Natural Science Foundation of China[11475231] ; National Natural Science Foundation of China[11505249]
WOS关键词	PROTON RADIOTHERAPY ; IRRADIATION SYSTEM ; PARTICLE THERAPY ; RIDGE FILTER ; OPTIMIZATION ; DESIGN ; EXTRACTION
WOS研究方向	Physics
语种	英语
出版者	CHINESE PHYSICAL SOC
WOS记录号	WOS:000412407200019
资助机构	Key Project of National Natural Science Foundation of China ; National Key Technology Support Program of the Ministry of Science and Technology of China ; National Key Research and Development Program of the Ministry of Science and Technology of China ; National Natural Science Foundation of China
内容类型	期刊论文
源URL	[http://119.78.100.186/handle/113462/45840]
专题	中国科学院近代物理研究所
通讯作者	Li, Qiang
作者单位	1.Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Peoples R China 2.Chinese Acad Sci, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou 730000, Gansu, Peoples R China 3.Key Lab Basic Res Heavy Ion Radiat Applicat Med, Lanzhou 730000, Gansu, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Yan, Yuan-Lin,Liu, Xin-Guo,Dai, Zhong-Ying,et al. Spot-scanning beam delivery with laterally-and longitudinally-mixed spot size pencil beams in heavy ion radiotherapy[J]. CHINESE PHYSICS C,2017,41:10.
APA	Yan, Yuan-Lin.,Liu, Xin-Guo.,Dai, Zhong-Ying.,Ma, Yuan-Yuan.,He, Peng-Bo.,...&Li, Qiang.(2017).Spot-scanning beam delivery with laterally-and longitudinally-mixed spot size pencil beams in heavy ion radiotherapy.CHINESE PHYSICS C,41,10.
MLA	Yan, Yuan-Lin,et al."Spot-scanning beam delivery with laterally-and longitudinally-mixed spot size pencil beams in heavy ion radiotherapy".CHINESE PHYSICS C 41(2017):10.