Acylphloroglucinol derivatives from Decaspermum gracilentum and their antiradical and cytotoxic activities

doi:10.1080/10286020.2015.1119129

	Acylphloroglucinol derivatives from Decaspermum gracilentum and their antiradical and cytotoxic activities
	Sun, Meng 1; Gobu, Fekadu-Roge 1; Pan, Dong 2,3; Li, Ya 1; Gao, Kun 1
刊名	JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
	2016-01-02
卷号	18 页码:13-19
关键词	acylphloroglucinol derivatives Myrtaceae cytotoxic activity Decaspermum gracilentum radical scavenging activity
ISSN号	1028-6020
DOI	10.1080/10286020.2015.1119129
英文摘要	Two new acylphloroglucinol derivatives, 1-(hexanoyl)phloroglucinol-alpha-d-arabinopyranoside (1) and 1-(hexanoyl)phloroglucinol-beta-d-glucopyranoside (2), along with two known ones, 1-(acetyl)phloroglucinol-beta-d-glucopyranoside (3) and ethyl 2,4,6-trihydroxybenzoate (4), were isolated from the EtOAc soluble fraction of EtOH extract of Decaspermum gracilentum. The structures of the new compounds were determined by extensive spectroscopic analyses including HRESIMS, 1D and 2D NMR data. Interestingly, all of the compounds showed ABTS(center dot+) radical scavenging activity with the IC50 values less than 10 mu M. Furthermore, compounds 3 and 4 displayed moderate cytotoxicity on human non-small-cell lung carcinoma cell line A549 (IC50=50.9 mu M) and human renal carcinoma cell line 786-O (IC50=38.6 mu M), respectively.
资助项目	National Basic Research Program (973) of China[2014CB138703] ; National Natural Science Foundation of China[31270396] ; National Natural Science Foundation of China[21402074]
WOS关键词	ANTIOXIDANT ACTIVITY
WOS研究方向	Plant Sciences ; Chemistry ; Pharmacology & Pharmacy
语种	英语
出版者	TAYLOR & FRANCIS LTD
WOS记录号	WOS:000371017700002
资助机构	National Basic Research Program (973) of China ; National Natural Science Foundation of China
内容类型	期刊论文
源URL	[http://119.78.100.186/handle/113462/41966]
专题	中国科学院近代物理研究所
通讯作者	Gao, Kun
作者单位	1.Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China 2.Chinese Acad Sci, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou 730000, Peoples R China 3.Chinese Acad Sci, Inst Modern Phys, Gansu Key Lab Space Radiobiol, Lanzhou 730000, Peoples R China
推荐引用方式 GB/T 7714	Sun, Meng,Gobu, Fekadu-Roge,Pan, Dong,et al. Acylphloroglucinol derivatives from Decaspermum gracilentum and their antiradical and cytotoxic activities[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2016,18:13-19.
APA	Sun, Meng,Gobu, Fekadu-Roge,Pan, Dong,Li, Ya,&Gao, Kun.(2016).Acylphloroglucinol derivatives from Decaspermum gracilentum and their antiradical and cytotoxic activities.JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,18,13-19.
MLA	Sun, Meng,et al."Acylphloroglucinol derivatives from Decaspermum gracilentum and their antiradical and cytotoxic activities".JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 18(2016):13-19.