Bacilohydrin A, a New Cytotoxic Cyclic Lipopeptide of Surfactins Class Produced by Bacillus sp. SY27F from the Indian Ocean Hydrothermal Vent | |
Zhou, Hong1; He, Yu2; Tian, Yongqi1; Cong, Bailin3; Yang, Huanghao2 | |
刊名 | NATURAL PRODUCT COMMUNICATIONS
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2019-01 | |
卷号 | 14期号:1页码:141-146 |
关键词 | Deep-sea hydrothermal vent Bacillus Cyclic lipopeptides Cytotoxicity |
ISSN号 | 1934-578X |
英文摘要 | Bacilohydrin A, a new cyclic lipopeptide composed of seven mixed (D/L)-amino acids ((L)-Ile(L)(1)-Leu(D)(2)-Asp(L)(3)-Val(L)(4)-Leu(L)(5)-Leu(L)(6)-Gln(7)) and a (R)-3-hydroxy-12-methyltetradecanoic acid (HMT) residue, was isolated from the crude culture extract of Bacillus sp. SY27F, which was obtained from the Indian Ocean hydrothermal vent. Its planar structure was elucidated by spectroscopic analyses, including 1D and 2D NMR spectroscopy, mass spectrometry (MS), and secondary ion mass spectrometry (MS/MS), whereas its absolute configuration was determined by modified Marfey's analysis. Bacilohydrin A displayed significant cytotoxicities against DU-145, MCF-7 and HepG2 cancer cell lines with IC50 values of 50.3-175.1 nM. Additionally, this is the first time to determine the absolute configuration of a D-aspartic acid residue in surfactin class. |
资助项目 | Natural Science Foundation of Fujian Provincial Department of Education[JAT170077] |
WOS研究方向 | Pharmacology & Pharmacy ; Food Science & Technology |
语种 | 英语 |
出版者 | SAGE PUBLICATIONS INC |
WOS记录号 | WOS:000469340700037 |
内容类型 | 期刊论文 |
源URL | [http://ir.fio.com.cn:8080/handle/2SI8HI0U/21491] ![]() |
专题 | 业务部门_海洋生态研究中心 |
通讯作者 | Tian, Yongqi; Cong, Bailin |
作者单位 | 1.Fuzhou Univ, Coll Biol Sci & Technol, Fuzhou 350116, Fujian, Peoples R China 2.Fuzhou Univ, Coll Chem, MOE Key Lab Analyt Sci Food Safety & Biol, State Key Lab Photocatalysis Energy & Environm, Fuzhou 350116, Fujian, Peoples R China 3.State Ocean Adm, Inst Oceanog 1, Qingdao 266061, Shandong, Peoples R China |
推荐引用方式 GB/T 7714 | Zhou, Hong,He, Yu,Tian, Yongqi,et al. Bacilohydrin A, a New Cytotoxic Cyclic Lipopeptide of Surfactins Class Produced by Bacillus sp. SY27F from the Indian Ocean Hydrothermal Vent[J]. NATURAL PRODUCT COMMUNICATIONS,2019,14(1):141-146. |
APA | Zhou, Hong,He, Yu,Tian, Yongqi,Cong, Bailin,&Yang, Huanghao.(2019).Bacilohydrin A, a New Cytotoxic Cyclic Lipopeptide of Surfactins Class Produced by Bacillus sp. SY27F from the Indian Ocean Hydrothermal Vent.NATURAL PRODUCT COMMUNICATIONS,14(1),141-146. |
MLA | Zhou, Hong,et al."Bacilohydrin A, a New Cytotoxic Cyclic Lipopeptide of Surfactins Class Produced by Bacillus sp. SY27F from the Indian Ocean Hydrothermal Vent".NATURAL PRODUCT COMMUNICATIONS 14.1(2019):141-146. |
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