Bacilohydrin A, a New Cytotoxic Cyclic Lipopeptide of Surfactins Class Produced by Bacillus sp. SY27F from the Indian Ocean Hydrothermal Vent

CORC > 自然资源部第一海洋研究所 > 自然资源部第一海洋研究所 > 业务部门 > 海洋生态研究中心

	Bacilohydrin A, a New Cytotoxic Cyclic Lipopeptide of Surfactins Class Produced by Bacillus sp. SY27F from the Indian Ocean Hydrothermal Vent
	Zhou, Hong 1; He, Yu 2; Tian, Yongqi 1; Cong, Bailin 3; Yang, Huanghao 2
刊名	NATURAL PRODUCT COMMUNICATIONS
	2019-01
卷号	14 期号:1 页码:141-146
关键词	Deep-sea hydrothermal vent Bacillus Cyclic lipopeptides Cytotoxicity
ISSN号	1934-578X
英文摘要	Bacilohydrin A, a new cyclic lipopeptide composed of seven mixed (D/L)-amino acids ((L)-Ile(L)(1)-Leu(D)(2)-Asp(L)(3)-Val(L)(4)-Leu(L)(5)-Leu(L)(6)-Gln(7)) and a (R)-3-hydroxy-12-methyltetradecanoic acid (HMT) residue, was isolated from the crude culture extract of Bacillus sp. SY27F, which was obtained from the Indian Ocean hydrothermal vent. Its planar structure was elucidated by spectroscopic analyses, including 1D and 2D NMR spectroscopy, mass spectrometry (MS), and secondary ion mass spectrometry (MS/MS), whereas its absolute configuration was determined by modified Marfey's analysis. Bacilohydrin A displayed significant cytotoxicities against DU-145, MCF-7 and HepG2 cancer cell lines with IC50 values of 50.3-175.1 nM. Additionally, this is the first time to determine the absolute configuration of a D-aspartic acid residue in surfactin class.
资助项目	Natural Science Foundation of Fujian Provincial Department of Education[JAT170077]
WOS研究方向	Pharmacology & Pharmacy ; Food Science & Technology
语种	英语
出版者	SAGE PUBLICATIONS INC
WOS记录号	WOS:000469340700037
内容类型	期刊论文
源URL	[http://ir.fio.com.cn:8080/handle/2SI8HI0U/21491]
专题	业务部门_海洋生态研究中心
通讯作者	Tian, Yongqi; Cong, Bailin
作者单位	1.Fuzhou Univ, Coll Biol Sci & Technol, Fuzhou 350116, Fujian, Peoples R China 2.Fuzhou Univ, Coll Chem, MOE Key Lab Analyt Sci Food Safety & Biol, State Key Lab Photocatalysis Energy & Environm, Fuzhou 350116, Fujian, Peoples R China 3.State Ocean Adm, Inst Oceanog 1, Qingdao 266061, Shandong, Peoples R China
推荐引用方式 GB/T 7714	Zhou, Hong,He, Yu,Tian, Yongqi,et al. Bacilohydrin A, a New Cytotoxic Cyclic Lipopeptide of Surfactins Class Produced by Bacillus sp. SY27F from the Indian Ocean Hydrothermal Vent[J]. NATURAL PRODUCT COMMUNICATIONS,2019,14(1):141-146.
APA	Zhou, Hong,He, Yu,Tian, Yongqi,Cong, Bailin,&Yang, Huanghao.(2019).Bacilohydrin A, a New Cytotoxic Cyclic Lipopeptide of Surfactins Class Produced by Bacillus sp. SY27F from the Indian Ocean Hydrothermal Vent.NATURAL PRODUCT COMMUNICATIONS,14(1),141-146.
MLA	Zhou, Hong,et al."Bacilohydrin A, a New Cytotoxic Cyclic Lipopeptide of Surfactins Class Produced by Bacillus sp. SY27F from the Indian Ocean Hydrothermal Vent".NATURAL PRODUCT COMMUNICATIONS 14.1(2019):141-146.