Two new compounds from the broth of the marine fungus Penicillium griseofulvum Y19-07

doi:10.1080/10286020903219923

	Two new compounds from the broth of the marine fungus Penicillium griseofulvum Y19-07
	Wang, Ya-Nan 1; Tian, Li 2,3; Hua, Hui-Ming 1; Lu, Xuan 1; Sun, Sha 1; Wu, Hong-Hua 1; Pei, Yue-Hu 1
刊名	JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
	2009
卷号	11 期号:11 页码:912-917
关键词	Penicillium griseofulvum marine fungus cytotoxicity
ISSN号	1028-6020
DOI	10.1080/10286020903219923
英文摘要	Two new compounds, 4-hydroxyphenethyl methyl succinate (1) and 4-hydroxyphenethyl 2-(4-hydroxyphenyl)acetate (2), were isolated from the EtOAc extract of the broth of the marine fungus Penicillium griseofulvum Y19-07. Five known compounds were also obtained in this study. The structures of the new compounds were elucidated by 1D and 2D NMR spectroscopy and mass spectrometry. All of the isolates were evaluated for their scavenging properties toward the 2,2-diphenyl-1-picrylhydrazyl free radical by spectroscopic assays. Also, in the cytotoxicity assay of the two new compounds against HL-60 and PC-3 prostate cancer cell lines, compound 2 showed potential activity with an IC50 value of 64.5 mu M against human HL-60 cancer cells.
资助项目	National Natural Science Foundation of China[40776098]
WOS关键词	NATURAL-PRODUCTS
WOS研究方向	Plant Sciences ; Chemistry ; Pharmacology & Pharmacy
语种	英语
出版者	TAYLOR & FRANCIS LTD
WOS记录号	WOS:000273723800002
内容类型	期刊论文
源URL	[http://ir.fio.com.cn:8080/handle/2SI8HI0U/27461]
专题	自然资源部第一海洋研究所
通讯作者	Pei, Yue-Hu
作者单位	1.Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Shenyang 110016, Peoples R China 2.First Inst Oceanog SOA, Qingdao 266061, Peoples R China 3.Qingdao Univ Sci & Technol, Dept Biol, Qingdao 266042, Peoples R China
推荐引用方式 GB/T 7714	Wang, Ya-Nan,Tian, Li,Hua, Hui-Ming,et al. Two new compounds from the broth of the marine fungus Penicillium griseofulvum Y19-07[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2009,11(11):912-917.
APA	Wang, Ya-Nan.,Tian, Li.,Hua, Hui-Ming.,Lu, Xuan.,Sun, Sha.,...&Pei, Yue-Hu.(2009).Two new compounds from the broth of the marine fungus Penicillium griseofulvum Y19-07.JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,11(11),912-917.
MLA	Wang, Ya-Nan,et al."Two new compounds from the broth of the marine fungus Penicillium griseofulvum Y19-07".JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 11.11(2009):912-917.