Pharmacological Profile of Xanthohumol, a Prenylated Flavonoid from Hops (Humulus lupulus)

doi:10.3390/molecules20010754

	Pharmacological Profile of Xanthohumol, a Prenylated Flavonoid from Hops (Humulus lupulus)
	Liu, Ming 1; Hansen, Poul Erik 2; Wang, Genzhu 1; Qiu, Lin 3; Dong, Jianjun 4; Yin, Hua 4; Qian, Zhonghua 4; Yang, Mei 4; Miao, Jinlai 4,5
刊名	MOLECULES
	2015-01
卷号	20 期号:1 页码:754-779
关键词	biological effects pharmacokinetics food additives beer metabolites
ISSN号	1420-3049
DOI	10.3390/molecules20010754
英文摘要	The female inflorescences of hops (Humulus lupulus L.), a well-known bittering agent used in the brewing industry, have long been used in traditional medicines. Xanthohumol (XN) is one of the bioactive substances contributing to its medical applications. Among foodstuffs XN is found primarily in beer and its natural occurrence is surveyed. In recent years, XN has received much attention for its biological effects. The present review describes the pharmacological aspects of XN and summarizes the most interesting findings obtained in the preclinical research related to this compound, including the pharmacological activity, the pharmacokinetics, and the safety of XN. Furthermore, the potential use of XN as a food additive considering its many positive biological effects is discussed.
资助项目	Open Research Fund of State Key Laboratory of Biological Fermentation Engineering of Beer[K2014002]
WOS关键词	TRAIL-INDUCED APOPTOSIS ; IN-VITRO ; CANCER-CELLS ; KAPPA-B ; DIACYLGLYCEROL ACYLTRANSFERASE ; MULTIDRUG-RESISTANCE ; CYTOKINE PRODUCTION ; DIETARY FLAVONOIDS ; DRUG TRANSPORTERS ; HYALURONAN EXPORT
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
语种	英语
出版者	MDPI
WOS记录号	WOS:000348319000044
内容类型	期刊论文
源URL	[http://ir.fio.com.cn:8080/handle/2SI8HI0U/25495]
专题	自然资源部第一海洋研究所
通讯作者	Liu, Ming
作者单位	1.Ocean Univ China, Key Lab Marine Drugs, Minist Educ, Sch Med & Pharm, Qingdao 266003, Peoples R China 2.Roskilde Univ, Dept Sci Syst & Models, DK-4000 Roskilde, Denmark 3.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Shanghai 200031, Peoples R China 4.State Key Lab Biol Fermentat Engn Beer, Qingdao 266061, Peoples R China 5.State Ocean Adm, Inst Oceanog 1, Key Lab Marine Bioact Subst, Qingdao 266061, Peoples R China
推荐引用方式 GB/T 7714	Liu, Ming,Hansen, Poul Erik,Wang, Genzhu,et al. Pharmacological Profile of Xanthohumol, a Prenylated Flavonoid from Hops (Humulus lupulus)[J]. MOLECULES,2015,20(1):754-779.
APA	Liu, Ming.,Hansen, Poul Erik.,Wang, Genzhu.,Qiu, Lin.,Dong, Jianjun.,...&Miao, Jinlai.(2015).Pharmacological Profile of Xanthohumol, a Prenylated Flavonoid from Hops (Humulus lupulus).MOLECULES,20(1),754-779.
MLA	Liu, Ming,et al."Pharmacological Profile of Xanthohumol, a Prenylated Flavonoid from Hops (Humulus lupulus)".MOLECULES 20.1(2015):754-779.