Structural analysis of SNARE motifs from sea perch, Lateolabrax japonicus by computerized approaches | |
Chen, Kui1,2,3; Huang, Xiaohang2 | |
刊名 | COMPUTATIONAL BIOLOGY AND CHEMISTRY
![]() |
2007-10-01 | |
卷号 | 31期号:5-6页码:378-383 |
关键词 | sea perch SNARE proteins motif 7S core complex protein structure analysis |
ISSN号 | 1476-9271 |
DOI | 10.1016/j.compbiolchem.2007.08-002 |
英文摘要 | Three cDNA sequences encoding four SNARE (N-ethylmaleimide-sensitive fusion protein attachment protein receptors) motifs were cloned from sea perch, and the deduced peptide sequences were analyzed for structural prediction by using 14 different web servers and softwares. The "ionic layer" structure, the three dimensional extension and conformational characters of the SNARE 7S core complex by using bioinformatics approaches were compared respectively with those from mammalian X-ray crystallographic investigations. The result suggested that the formation and stabilization of fish SNARE core complex might be driven by hydrophobic association, hydrogen bond among R group of core amino acids and electrostatic attraction at molecular level. This revealed that the SNARE proteins interaction of the fish may share the same molecular mechanism with that of mammal, indicating the universality and solidity of SNARE core complex theory. This work is also an attempt to get the protein 3D structural information which appears to be similar to that obtained through X-ray crystallography, only by using computerized approaches. (C) 2007 Elsevier Ltd. All rights reserved. |
WOS研究方向 | Life Sciences & Biomedicine - Other Topics ; Computer Science |
语种 | 英语 |
出版者 | ELSEVIER SCI LTD |
WOS记录号 | WOS:000250912400009 |
内容类型 | 期刊论文 |
源URL | [http://ir.fio.com.cn/handle/2SI8HI0U/4550] ![]() |
专题 | 自然资源部第一海洋研究所 |
作者单位 | 1.Institute of Oceanology, Chinese Academy of Sciences, Qingdao, 266071, China; 2.The First Institute of Oceanography, State Oceanic Administration, Qingdao, 266061, China; 3.Graduate University, Chinese Academy of Sciences, Beijing, 100039, China |
推荐引用方式 GB/T 7714 | Chen, Kui,Huang, Xiaohang. Structural analysis of SNARE motifs from sea perch, Lateolabrax japonicus by computerized approaches[J]. COMPUTATIONAL BIOLOGY AND CHEMISTRY,2007,31(5-6):378-383. |
APA | Chen, Kui,&Huang, Xiaohang.(2007).Structural analysis of SNARE motifs from sea perch, Lateolabrax japonicus by computerized approaches.COMPUTATIONAL BIOLOGY AND CHEMISTRY,31(5-6),378-383. |
MLA | Chen, Kui,et al."Structural analysis of SNARE motifs from sea perch, Lateolabrax japonicus by computerized approaches".COMPUTATIONAL BIOLOGY AND CHEMISTRY 31.5-6(2007):378-383. |
个性服务 |
查看访问统计 |
相关权益政策 |
暂无数据 |
收藏/分享 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论