Estimation of AUC or Partial AUC Under Test-Result-Dependent Sampling

doi:10.1080/19466315.2012.692514

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	Estimation of AUC or Partial AUC Under Test-Result-Dependent Sampling
	Wang, Xiaofei 1; Ma, Junling 2; George, Stephen 1; Zhou, Haibo 3
刊名	STATISTICS IN BIOPHARMACEUTICAL RESEARCH
	2012-11
卷号	4 期号:4 页码:313-323
关键词	Area under ROC curve (AUC) Empirical likelihood Nonparametric Partial area under ROC curve (pAUC) Simple random sampling (SRS) Test-result-dependent-sampling (TDS)
ISSN号	1946-6315
DOI	10.1080/19466315.2012.692514
英文摘要	The area under the receiver operating characteristic (ROC) curve (AUC) and partial area under the ROC curve (pAUC) are summary measures used to assess the accuracy of a biomarker in discriminating true disease status. The standard sampling approach used in biomarker validation studies is often inefficient and costly, especially when ascertaining the true disease status is costly and invasive. To improve efficiency and reduce the cost of biomarker validation studies, we consider a test-result-dependent sampling (TDS) scheme, in which subject selection for determining the disease state is dependent on the result of a biomarker assay. We first estimate the test-result distribution using data arising from the TDS design. With the estimated empirical test-result distribution, we propose consistent nonparametric estimators for AUC and pAUC and establish the asymptotic properties of the proposed estimators. Simulation studies show that the proposed estimators have good finite sample properties and that the TDS design yields more efficient AUC and pAUC estimates than a simple random sampling design. A data example based on an ongoing cancer clinical trial is provided to illustrate the TDS design and the proposed estimators. This work can find broad applications in the design and analysis of biomarker validation studies.
WOS研究方向	Mathematical & Computational Biology ; Mathematics
语种	英语
出版者	AMER STATISTICAL ASSOC
WOS记录号	WOS:000309751000001
内容类型	期刊论文
源URL	[http://10.2.47.112/handle/2XS4QKH4/2091]
专题	上海财经大学
通讯作者	Wang, Xiaofei
作者单位	1.Duke Univ, Med Ctr, Dept Biostat & Bioinformat, Durham, NC 27710 USA; 2.Shanghai Univ Finance & Econ, Res Ctr Appl Stat, Sch Stat & Management, Shanghai 200433, Peoples R China; 3.Univ N Carolina, Dept Biostat, Chapel Hill, NC 27599 USA
推荐引用方式 GB/T 7714	Wang, Xiaofei,Ma, Junling,George, Stephen,et al. Estimation of AUC or Partial AUC Under Test-Result-Dependent Sampling[J]. STATISTICS IN BIOPHARMACEUTICAL RESEARCH,2012,4(4):313-323.
APA	Wang, Xiaofei,Ma, Junling,George, Stephen,&Zhou, Haibo.(2012).Estimation of AUC or Partial AUC Under Test-Result-Dependent Sampling.STATISTICS IN BIOPHARMACEUTICAL RESEARCH,4(4),313-323.
MLA	Wang, Xiaofei,et al."Estimation of AUC or Partial AUC Under Test-Result-Dependent Sampling".STATISTICS IN BIOPHARMACEUTICAL RESEARCH 4.4(2012):313-323.