Longitudinal covariate-adjusted response-adaptive randomized designs

doi:10.1016/j.jspi.2013.04.004

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	Longitudinal covariate-adjusted response-adaptive randomized designs
	Huang, Tao 1; Liu, Zhongqiang 3; Hu, Feifang 2,3
刊名	JOURNAL OF STATISTICAL PLANNING AND INFERENCE
	2013-10
卷号	143 期号:10 页码:1816-1827
关键词	Asymptotic properties Clinical trial Continuous response Covariate-adjusted response-adaptive design Treatment allocation
ISSN号	0378-3758
DOI	10.1016/j.jspi.2013.04.004
英文摘要	Clinical trials often involve longitudinal data set which has two important characteristics: repeated and correlated measurements and time-varying covariates. In this paper, we propose a general framework of longitudinal covariate-adjusted response-adaptive (LCARA) randomization procedures. We study their properties under widely satisfied conditions. This design skews the allocation probabilities which depend on both patients' first observed covariates and sequentially estimated parameters based on the accrued longitudinal responses and covariates. The asymptotic properties of estimators for the unknown parameters and allocation proportions are established. The special case of binary treatment and continuous responses is studied in detail. Simulation studies and an analysis of the National Cooperative Gallstone Study (NCGS) data are carried out to illustrate the advantages of the proposed LCARA randomization procedure. (C) 2013 Elsevier B.V. All rights reserved.
WOS研究方向	Mathematics
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000323809800017
内容类型	期刊论文
源URL	[http://10.2.47.112/handle/2XS4QKH4/1921]
专题	上海财经大学
通讯作者	Hu, Feifang
作者单位	1.Shanghai Univ Finance & Econ, Sch Stat & Management, Shanghai, Peoples R China; 2.Univ Virginia, Dept Stat, Charlottesville, VA 22903 USA; 3.Renmin Univ China, Sch Stat, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Huang, Tao,Liu, Zhongqiang,Hu, Feifang. Longitudinal covariate-adjusted response-adaptive randomized designs[J]. JOURNAL OF STATISTICAL PLANNING AND INFERENCE,2013,143(10):1816-1827.
APA	Huang, Tao,Liu, Zhongqiang,&Hu, Feifang.(2013).Longitudinal covariate-adjusted response-adaptive randomized designs.JOURNAL OF STATISTICAL PLANNING AND INFERENCE,143(10),1816-1827.
MLA	Huang, Tao,et al."Longitudinal covariate-adjusted response-adaptive randomized designs".JOURNAL OF STATISTICAL PLANNING AND INFERENCE 143.10(2013):1816-1827.