Decreased brain connectivity in smoking contrasts with increased connectivity in drinking

doi:10.7554/eLife.40765

CORC > 上海财经大学 > 上海财经大学

	Decreased brain connectivity in smoking contrasts with increased connectivity in drinking
	Cheng, Wei 1,2,3; Rolls, Edmund T.1,3,4; Robbins, Trevor W.5,6; Gong, Weikang 1,7; Liu, Zhaowen 8; Lv, Wujun 9; Du, Jingnan 1; Wen, Hongkai 3; Ma, Liang 10; Quinlan, Erin Burke 11,12
刊名	ELIFE
	2019-01-08
卷号	8
ISSN号	2050-084X
DOI	10.7554/eLife.40765
英文摘要	In a group of 831 participants from the general population in the Human Connectome Project, smokers exhibited low overall functional connectivity, and more specifically of the lateral orbitofrontal cortex which is associated with non-reward mechanisms, the adjacent inferior frontal gyrus, and the precuneus. Participants who drank a high amount had overall increases in resting state functional connectivity, and specific increases in reward-related systems including the medial orbitofrontal cortex and the cingulate cortex. Increased impulsivity was found in smokers, associated with decreased functional connectivity of the non-reward-related lateral orbitofrontal cortex; and increased impulsivity was found in high amount drinkers, associated with increased functional connectivity of the reward-related medial orbitofrontal cortex. The main findings were cross-validated in an independent longitudinal dataset with 1176 participants, IMAGEN. Further, the functional connectivities in 14-year-old non-smokers (and also in female low-drinkers) were related to who would smoke or drink at age 19. An implication is that these differences in brain functional connectivities play a role in smoking and drinking, together with other factors.
WOS研究方向	Life Sciences & Biomedicine - Other Topics
语种	英语
出版者	ELIFE SCIENCES PUBLICATIONS LTD
WOS记录号	WOS:000455875700001
内容类型	期刊论文
源URL	[http://10.2.47.112/handle/2XS4QKH4/372]
专题	上海财经大学
通讯作者	Feng, Jianfeng
作者单位	1.Fudan Univ, Inst Sci & Technol Braininspired Intelligence, Shanghai, Peoples R China; 2.Fudan Univ, Minist Educ, Key Lab Computat Neurosci & Braininspired Intelli, Shanghai, Peoples R China; 3.Univ Warwick, Dept Comp Sci, Coventry, W Midlands, England; 4.Oxford Ctr Computat Neurosci, Oxford, England; 5.Univ Cambridge, Behav & Clin Neurosci Inst, Cambridge, England; 6.Univ Cambridge, Dept Psychol, Cambridge, England; 7.Univ Chinese Acad Sci, Beijing, Peoples R China; 8.Xidian Univ, Sch Comp Sci & Technol, Xian, Shaanxi, Peoples R China; 9.Shanghai Univ Finance & Econ, Sch Math, Shanghai, Peoples R China; 10.Chinese Acad Sci, Beijing Inst Genom, Beijing, Peoples R China;
推荐引用方式 GB/T 7714	Cheng, Wei,Rolls, Edmund T.,Robbins, Trevor W.,et al. Decreased brain connectivity in smoking contrasts with increased connectivity in drinking[J]. ELIFE,2019,8.
APA	Cheng, Wei.,Rolls, Edmund T..,Robbins, Trevor W..,Gong, Weikang.,Liu, Zhaowen.,...&Feng, Jianfeng.(2019).Decreased brain connectivity in smoking contrasts with increased connectivity in drinking.ELIFE,8.
MLA	Cheng, Wei,et al."Decreased brain connectivity in smoking contrasts with increased connectivity in drinking".ELIFE 8(2019).