Spatiotemporal establishment of dense bacterial colonies growing on hard agar

doi:10.7554/eLife.41093

CORC > 上海财经大学 > 上海财经大学

	Spatiotemporal establishment of dense bacterial colonies growing on hard agar
	Warren, Mya R.1; Sun, Hui 1,2,3; Yan, Yue 2,4,5; Cremer, Jonas 1,6; Li, Bo 2; Hwa, Terence 1
刊名	ELIFE
	2019-03-11
卷号	8
ISSN号	2050-084X
DOI	10.7554/eLife.41093
英文摘要	The physical interactions of growing bacterial cells with each other and with their surroundings significantly affect the structure and dynamics of biofilms. Here a 3D agent-based model is formulated to describe the establishment of simple bacterial colonies expanding by the physical force of their growth. With a single set of parameters, the model captures key dynamical features of colony growth by non-motile, non EPS-producing E. coil cells on hard agar. The model, supported by experiment on colony growth in different types and concentrations of nutrients, suggests that radial colony expansion is not limited by nutrients as commonly believed, but by mechanical forces. Nutrient penetration instead governs vertical colony growth, through thin layers of vertically oriented cells lifting up their ancestors from the bottom. Overall, the model provides a versatile platform to investigate the influences of metabolic and environmental factors on the growth and morphology of bacterial colonies.
WOS研究方向	Life Sciences & Biomedicine - Other Topics
语种	英语
出版者	ELIFE SCIENCES PUBLICATIONS LTD
WOS记录号	WOS:000460929900001
内容类型	期刊论文
源URL	[http://10.2.47.112/handle/2XS4QKH4/315]
专题	上海财经大学
作者单位	1.Univ Calif San Diego, Dept Phys, La Jolla, CA 92093 USA; 2.Univ Calif San Diego, Dept Math, La Jolla, CA 92093 USA; 3.Calif State Univ Long Beach, Dept Math & Stat, Long Beach, CA 90840 USA; 4.Fudan Univ, Sch Math Sci, Shanghai, Peoples R China; 5.Shanghai Univ Finance & Econ, Sch Math, Shanghai, Peoples R China; 6.Univ Groningen, Groningen Biomol Sci & Biotechnol Inst, Groningen, Netherlands
推荐引用方式 GB/T 7714	Warren, Mya R.,Sun, Hui,Yan, Yue,et al. Spatiotemporal establishment of dense bacterial colonies growing on hard agar[J]. ELIFE,2019,8.
APA	Warren, Mya R.,Sun, Hui,Yan, Yue,Cremer, Jonas,Li, Bo,&Hwa, Terence.(2019).Spatiotemporal establishment of dense bacterial colonies growing on hard agar.ELIFE,8.
MLA	Warren, Mya R.,et al."Spatiotemporal establishment of dense bacterial colonies growing on hard agar".ELIFE 8(2019).