Overcoming foreign-body reaction through nanotopography: Biocompatibility and immunoisolation properties of a nanofibrous membrane | |
Wang, Kai ; Hou, Wen-Da ; Wang, Xi ; Han, Chengsheng ; Vuletic, Ivan ; Su, Ni ; Zhang, Wen-Xi ; Ren, Qiu-Shi ; Chen, Liangyi ; Luo, Ying | |
刊名 | BIOMATERIALS |
2016 | |
关键词 | Macroencapsulation Foreign body response Cell transplantation Electrospun membrane Nanofiber MESENCHYMAL STEM-CELLS MACROPHAGE PHENOTYPE MECHANICAL-PROPERTIES POLYMER FIBERS POLARIZATION SCAFFOLDS PRIMATES ISLETS MICE NEOVASCULARIZATION |
DOI | 10.1016/j.biomaterials.2016.06.028 |
英文摘要 | Implantable immunoisolation membranes need to possess superior biocompatibility to prohibit the fibrotic deposition that would reduce the nutrient supply and impair the viability/function of the encapsulated cells. Here, electrospun membranes based on thermoplastic polyurethane (TPU) were fabricated to contain microfibers (PU-micro) or nanofibers (PU-nano). The two types of membranes were compared in terms of their interaction with macrophage cells and the host tissues. It was found that the fibrous membranes of different topographies possess distinct material properties: PU-nano caused minimal macrophage responses in vitro and in vivo and induced only mild foreign body reactions compared to PU-micro membranes. A flat macroencapsulation device was fabricated using PU-nano membranes and its immunoisolation function investigated in subcutaneous transplantation models. The nanofibrous device demonstrated the capability to effectively shield the allografts from the immune attack of the host. Nanotopography may confer biocompatibility to materials and nanofibrous materials warrant further study for development of "invisible" immunoisolation devices for cell transplantation. (C) 2016 Elsevier Ltd. All rights reserved.; National Natural Science Foundation of China [31322021]; SCI(E); EI; PubMed; ARTICLE; ying.luo@pku.edu.cn; 249-258; 102 |
语种 | 英语 |
内容类型 | 期刊论文 |
源URL | [http://ir.pku.edu.cn/handle/20.500.11897/493605] |
专题 | 工学院 |
推荐引用方式 GB/T 7714 | Wang, Kai,Hou, Wen-Da,Wang, Xi,et al. Overcoming foreign-body reaction through nanotopography: Biocompatibility and immunoisolation properties of a nanofibrous membrane[J]. BIOMATERIALS,2016. |
APA | Wang, Kai.,Hou, Wen-Da.,Wang, Xi.,Han, Chengsheng.,Vuletic, Ivan.,...&Luo, Ying.(2016).Overcoming foreign-body reaction through nanotopography: Biocompatibility and immunoisolation properties of a nanofibrous membrane.BIOMATERIALS. |
MLA | Wang, Kai,et al."Overcoming foreign-body reaction through nanotopography: Biocompatibility and immunoisolation properties of a nanofibrous membrane".BIOMATERIALS (2016). |
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